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Database: UniProt
Entry: C0H8I2
LinkDB: C0H8I2
Original site: C0H8I2 
ID   SETD6_SALSA             Reviewed;         449 AA.
AC   C0H8I2;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   16-JAN-2019, entry version 29.
DE   RecName: Full=N-lysine methyltransferase setd6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=setd6;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A.,
RA   Messmer A.M., Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J.,
RA   Davidson W.S., Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes
RT   in evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SETD6 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
DR   EMBL; BT058638; ACN10351.1; -; mRNA.
DR   EMBL; BT060351; ACN12711.1; -; mRNA.
DR   RefSeq; NP_001158764.1; NM_001165292.1.
DR   UniGene; Ssa.27270; -.
DR   GeneID; 100306753; -.
DR   KEGG; sasa:100306753; -.
DR   CTD; 79918; -.
DR   KO; K05302; -.
DR   OrthoDB; 490654at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    449       N-lysine methyltransferase setd6.
FT                                /FTId=PRO_0000405842.
FT   DOMAIN       32    257       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   449 AA;  51445 MW;  558801AA0F4F1386 CRC64;
     MATDAKRLKT EGSDPLQSFL QWCEGVGLKL NNKVYISKEG TVAEYGMLAK EDIDEGELLF
     TIPRMALLHQ GTTKVLAVLE EGKASLENTS GWVPLLLALM YEYTSPQSHW RPYLSLWSDF
     TALDHPMFWS KDERDRLLKG TGIPEAVDTD LTNIQKEYKD IVLPFITLHP DLWDPERHTL
     DLYRSLVAFV MAYSFQEPLD EEDEDEKDPN PPMMVPIADM LNHVSNHNAN LEYTPECLKM
     VSVRSIRKGE EVFNTYGQMA NWQLLHMYGL XEPYQSNSND TADIPMSNVY KAAVQVTRSE
     AEQRLLVEKW SLLCEMEMVG DKGVFIFGKS GSLTDTEMYT TLKILCMSVE EFEDFRENEG
     WEEADDDEEK MLQALSNEGL PSLPPVWRCL VHAAARFTLD SYGEDMLKDK VLLEDKDGYA
     KLSSRQRRAL QVRYGQKTIL HQLLELTKP
//
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