ID C0H932_SALSA Unreviewed; 214 AA.
AC C0H932;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Metalloproteinase inhibitor 3 {ECO:0000256|ARBA:ARBA00013517};
DE AltName: Full=Tissue inhibitor of metalloproteinases 3 {ECO:0000256|ARBA:ARBA00030101};
GN Name=TIMP3 {ECO:0000313|EMBL:ACN10551.1};
GN Synonyms=LOC106609153 {ECO:0000313|RefSeq:XP_014063110.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACN10551.1};
RN [1] {ECO:0000313|EMBL:ACN10551.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10551.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN10551.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10551.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACN10551.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10551.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:XP_014063110.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014063110.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR EMBL; BT058838; ACN10551.1; -; mRNA.
DR RefSeq; XP_014063110.1; XM_014207635.1.
DR STRING; 8030.ENSSSAP00000096913; -.
DR MEROPS; I35.003; -.
DR PaxDb; 8030-ENSSSAP00000096913; -.
DR Ensembl; ENSSSAT00000131282; ENSSSAP00000096899; ENSSSAG00000073256.
DR GeneID; 106609153; -.
DR KEGG; sasa:106609153; -.
DR OMA; PFGKCET; -.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000087266; Chromosome ssa07.
DR Bgee; ENSSSAG00000073256; Expressed in pharyngeal gill and 16 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd03585; NTR_TIMP; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF22; METALLOPROTEINASE INHIBITOR 3; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..214
FT /note="Metalloproteinase inhibitor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010827480"
FT DOMAIN 27..146
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 27..94
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 29..121
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 39..146
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 148..195
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 153..158
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 166..187
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 214 AA; 24736 MW; EA434C6A621808EE CRC64;
MQSLCHRLLS LLFVFSSLQI HQLTEACSCA LSHPQDAYCN SDIVIRAKVV GKKLMKDGPF
GTMRYTVKQM KMYKGFNKMQ HVQHIYTDAS ESLCGVKFDI NKYQYLITGR VFDGKVYTGL
CNFNQPWERL SLAQKKGINH RYQLGCNCRI KPCHYLPCFV TSKNECLWTD MLSHFGYPGY
QSRHYACIQQ KEGYCSWYRG MAGRDKTTIN STDP
//