ID C0H978_SALSA Unreviewed; 599 AA.
AC C0H978;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Male-specific lethal 2-like 1 {ECO:0000313|EMBL:ACN10597.1, ECO:0000313|RefSeq:NP_001167043.1};
GN Name=MSL2 {ECO:0000313|EMBL:ACN10597.1};
GN Synonyms=msl2 {ECO:0000313|RefSeq:NP_001167043.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACN10597.1};
RN [1] {ECO:0000313|EMBL:ACN10597.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10597.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN10597.1, ECO:0000313|RefSeq:NP_001167043.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10597.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACN10597.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10597.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001167043.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BT058884; ACN10597.1; -; mRNA.
DR RefSeq; NP_001167043.1; NM_001173572.1.
DR STRING; 8030.ENSSSAP00000108888; -.
DR PaxDb; 8030-ENSSSAP00000108888; -.
DR Ensembl; ENSSSAT00000143744; ENSSSAP00000108888; ENSSSAG00000077499.
DR GeneID; 100380287; -.
DR KEGG; sasa:100380287; -.
DR CTD; 55167; -.
DR OMA; TNQDVPP; -.
DR OrthoDB; 4153116at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR Bgee; ENSSSAG00000077499; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0072487; C:MSL complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR CDD; cd13122; MSL2_CXC; 1.
DR CDD; cd16522; RING-HC_MSL2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037922; MSL2.
DR InterPro; IPR032049; Msl2-CXC.
DR InterPro; IPR032043; Msl2_Znf-RING.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16048:SF3; E3 UBIQUITIN-PROTEIN LIGASE MSL2; 1.
DR PANTHER; PTHR16048; MSL2-RELATED; 1.
DR Pfam; PF16682; MSL2-CXC; 1.
DR Pfam; PF16685; zf-RING_10; 1.
DR SMART; SM01114; CXC; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 44..85
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 140..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 64242 MW; 818BD9EE5A85938B CRC64;
MNPVNATTLY VSACRSVLQC DPRDPRALAE LYKLLPFFRQ SLSCLVCGNL LQDPIAPTNS
QCQHYVCRGC KGQRMLLKPS CSWCKDYSRF QENRQLSLLV HCYRKLCLYI AQSPLAPHIA
SAASDSPDLL AILNEGLSLA ESGQEGEDTE SQSPPTAPST SGLRPDEAPA EEESQEEGLS
PVGGVNGLHD CNGLTNQDVP PPVTLATGGG VLKQESLGEE LPVCVGMLGS GEVGLCDIST
FGEELNKHGG DTLLLSVEEV LRTLEPEPEP PDPQPDFPSI PPHNGSYCHP THDSPCLTPS
LPSENIPRLP LPLPQPIPVL SRLPPRCHRK RSRSESDSEK VQPLPIASIL RGSPLSTTNA
SHLPNPAATV KREPKLHSAI TPPHLAPVPN GGPPKLGKTM LVSSKGLKKS LEHHGGPKKA
YSKARQGVPK PRAQPRDRLP PHPHGHAHPL SHPPSPSKPL YKKPVEKKGC KCGRATQNPS
VLTCRGQRCP CYSNRKACLD CICRGCQNSY MANGEKKLEA FAVPEKALEQ TRLTLGINLT
SITAAALRSP ATSNTQHGNQ LITTATGASG VTGVSFLSGV GAGHEDRGFD DSLDMRFDC
//
