ID C0H9N4_SALSA Unreviewed; 724 AA.
AC C0H9N4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Exostosin-2 {ECO:0000313|EMBL:ACN10753.1, ECO:0000313|RefSeq:NP_001167078.1};
GN Name=EXT2 {ECO:0000313|EMBL:ACN10753.1};
GN Synonyms=ext2 {ECO:0000313|RefSeq:NP_001167078.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACN10753.1};
RN [1] {ECO:0000313|EMBL:ACN10753.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10753.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN10753.1, ECO:0000313|RefSeq:NP_001167078.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10753.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACN10753.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10753.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001167078.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR EMBL; BT059040; ACN10753.1; -; mRNA.
DR RefSeq; NP_001167078.1; NM_001173607.1.
DR STRING; 8030.ENSSSAP00000058271; -.
DR GeneID; 100380322; -.
DR KEGG; sasa:100380322; -.
DR CTD; 2132; -.
DR OMA; NCTFWDC; -.
DR OrthoDB; 1220028at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR Bgee; ENSSSAG00000054855; Expressed in nose and 16 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..386
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 462..707
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
FT COILED 261..288
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 724 AA; 82883 MW; AB7EE927CF20B43C CRC64;
MVRLSMCASG KYSSRGPALI PRMKTKHRIY YITLFSVVLL GLIATGMFQF WPHSIESTAD
WGLDRRSVHD APLVRLPISN PIPERGDLSC RMHTCFDVYR CGYNPKNRIK VYIYPLQRFV
DEVGVPISST GLSREYNDLL SAISDSEFYT DDVTRACLFV PSIDVLNQNS LRIRETAQAL
AMLPRWDKGM NHLLFNMLPG GPPDYNTALD VPRDRALLAG GGFSTWTYRQ GYDISIPVYS
PLSADVELPE RQPGPRRYFI LSSQTAIHRE YRAELERLKE ENGEALLLLD KCSNLSQGAA
SARKRCYKGQ VFDYPQILQE SSFCVVLRGA RLGQATLSDV LQAGCVPVIL ADSYILPFSE
VLDWKRASVV IPEEKLPEMY TILKSIPHRQ VEEMQRQARW FWDAYFSSMK AIGMTTLQII
NDRIYPYAAR TYEQWNNPPL VKWSSVNSPL FLPLIPPRSP GFTAVVLTYD RIESLFRVIT
EISKVPSLAK LLVVWNNQNK SPPEDSLWPK IAVPLKVVRT KENKLSNRFF PYDEIETEAV
LAIDDDIIML TSDELQFGYE VWRELPDRLV GYPGRLHLWD HEMGKWKYES EWTNEVSMVL
TGAAFYHKYF NYLYTYKMPG DIKNWVDAHM NCEDIAMNFL VANITGKAPI KVTPRKKFKC
PECTAIDGLS LDQTHMVERS ECINKFASVF GTMPLKVVEH RADPVLYKDD FPEKLKSFPN
IGSL
//
