ID C0HBI8_SALSA Unreviewed; 709 AA.
AC C0HBI8;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN Name=PPCE {ECO:0000313|EMBL:ACN11407.1};
GN Synonyms=ppce {ECO:0000313|RefSeq:NP_001167336.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACN11407.1};
RN [1] {ECO:0000313|EMBL:ACN11407.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN11407.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN11407.1, ECO:0000313|RefSeq:NP_001167336.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN11407.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACN11407.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN11407.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001167336.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR EMBL; BT059694; ACN11407.1; -; mRNA.
DR RefSeq; NP_001167336.1; NM_001173865.1.
DR STRING; 8030.ENSSSAP00000031915; -.
DR MEROPS; S09.001; -.
DR PaxDb; 8030-ENSSSAP00000031915; -.
DR GeneID; 100380580; -.
DR KEGG; sasa:100380580; -.
DR CTD; 100305172; -.
DR OrthoDB; 7264at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF4; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368024};
KW Protease {ECO:0000256|RuleBase:RU368024};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Serine protease {ECO:0000256|RuleBase:RU368024}.
FT DOMAIN 6..421
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 490..704
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 709 AA; 80015 MW; 0EA97A9C2A060C84 CRC64;
MAFKYPAARR DESKVDDYHG VKIYDPYAWL EDPDSDETKA FVEEQNKLTM PFLEQCAVRP
QFHQRLTELY DYPKYSCPYK RGNRYFYFHN QGLQNQDALY VQDSLDGLAT VFFDPNTLSE
DGTVALKMGR LSEECEYFAY GLSSSGSDWV TVHFLKADDL MKLPDVLDRV KFSCLAWTHD
ARGVFYNCYP RQDGKADGTE TTSNLNQKLY YHVIGTNQSE DILVAEFPDN PKWHSGVTVS
DDGRYAVLDI TEGCEPVNQL WYCDLQKLPN GITGLLPWVK LVANFEAQYS YITNEGSVFT
FRTNLDAPRY CLINIDLEKP DKDHWRTLLP QHDKDVLGSV ACVNQHHLVV NYVHDVKDIL
QLYELSTGGL VRDLPLDVGT VVGLSCKKKH SDFFYKFTSF TTPGVIYHCD LSKASPEPTV
FRQVEVKGIQ QEDYETNQVF YPSKDGTKIP MFLVHARGLK KDGSHPVFLY GYGGFENSIQ
PYYNVPYLLF VRHLGGILAV ANIRGGGEYG QTWHKGGILG NKMNCFDDFQ CAAEYLIQEN
YTTASRIAIN GASNGGLLVA ACVNQRPDLF GCAVAEVGVM DMLKFHKFTI GHAWTTDYGC
ADHPEQFKWL IKYSPLHNLP PSPYAGTAYP AMLLLTADHD DRVVPLHTLK YCATLQHGVG
SSPGQRQPLM VRVDTRSGHG AGKPTAKAIL EDTHIFSFIA QTLGLSWRE
//
