ID C0LZL0_PIG Unreviewed; 493 AA.
AC C0LZL0; F1RFN9; I3LKF3;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN Name=FSCN1 {ECO:0000313|EMBL:ACN89281.1,
GN ECO:0000313|Ensembl:ENSSSCP00000024567.3,
GN ECO:0000313|VGNC:VGNC:88248};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ACN89281.1};
RN [1] {ECO:0000313|EMBL:ACN89281.1}
RP NUCLEOTIDE SEQUENCE.
RA Tang Z., Zhang X., Li K.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000024567.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024567.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACN89281.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19688270; DOI=10.1007/s11033-009-9742-9;
RA Tang Zh.L., Zhang X.J., Yang Sh.L., Mu Y.L., Cui W.T., Ao H., Li K.;
RT "The chromosomal localization, expression pattern and polymorphism analysis
RT of porcine FSCN1 gene differently expressed from LongSAGE library.";
RL Mol. Biol. Rep. 37:2361-2367(2010).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000024567.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR EMBL; FJ790418; ACN89281.1; -; mRNA.
DR RefSeq; NP_001139772.1; NM_001146300.1.
DR STRING; 9823.ENSSSCP00000024567; -.
DR PaxDb; 9823-ENSSSCP00000024567; -.
DR Ensembl; ENSSSCT00000026008.4; ENSSSCP00000024567.3; ENSSSCG00000007586.5.
DR GeneID; 100286741; -.
DR KEGG; ssc:100286741; -.
DR CTD; 6624; -.
DR VGNC; VGNC:88248; FSCN1.
DR eggNOG; ENOG502QPRX; Eukaryota.
DR GeneTree; ENSGT00950000183157; -.
DR HOGENOM; CLU_030960_2_0_1; -.
DR OMA; NIFSMTR; -.
DR OrthoDB; 5484756at2759; -.
DR TreeFam; TF323992; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007586; Expressed in granulosa cell and 40 other cell types or tissues.
DR Genevisible; C0LZL0; SS.
DR GO; GO:0031253; C:cell projection membrane; IEA:Ensembl.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0044393; C:microspike; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007043; P:cell-cell junction assembly; IEA:Ensembl.
DR GO; GO:0035089; P:establishment of apical/basal cell polarity; IEA:Ensembl.
DR GO; GO:0030035; P:microspike assembly; IEA:Ensembl.
DR GO; GO:0030046; P:parallel actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0090091; P:positive regulation of extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0032534; P:regulation of microvillus assembly; IEA:Ensembl.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Proteomics identification {ECO:0007829|PeptideAtlas:C0LZL0};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 21..134
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 143..256
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 268..377
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 392..493
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 493 AA; 54683 MW; 1C1306489A7B9F1E CRC64;
MTANGTAEAL QIQFGLINCS NKYLTAETFG FKVNASASSL KKKQIWTLEQ PPDEAGGAAM
CLRSHLGRYL AADKDGNVTC EHEVPDADCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS
CFAQTVSPAE KWSVHIAMHP QVNIYSLARK RYAHLSARPA DEISVDRDVP WGVDSLITLA
FQDQRYSLQT ADHRFLRHDG RLVEQPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDG
DTKKCAFRTH SGKYWTLTAS GGVQSTASSK DASCYFDIEW RDRRIILRAS NGKFVTAKKN
GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSN YDVFQLEFRD
GAYNIKDSTG KYWMVGTDSS VTSSSDTPVD FFFEFLDYNK VAIKVGGHYL KGDHAGVLKA
CADAIDPATL WEY
//
