ID C0NBN5_AJECG Unreviewed; 1140 AA.
AC C0NBN5;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=DUF726 domain-containing protein {ECO:0000313|EMBL:EEH11076.1};
GN ORFNames=HCBG_00531 {ECO:0000313|EMBL:EEH11076.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH11076.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG663363; EEH11076.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NBN5; -.
DR ESTHER; ajecg-c0nbn5; Duf_726.
DR VEuPathDB; FungiDB:I7I50_02387; -.
DR HOGENOM; CLU_001695_1_0_1; -.
DR InParanoid; C0NBN5; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 543..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 124822 MW; 3C1D1EBB5A60BD1B CRC64;
MNPVADASKC LDSSETAPAP AKAGENGALT PPCSSILSST NTNKLEMANL VKSNTEGKLQ
LADIDEFGLP IQNLSQSAQP NNDELPDPEN QMKTAEESTQ ESSLSKNDEA AFTTTSNTIL
PSTQKERVSQ STSTISLSNM AKELPTIDPP DISKNPDKPQ SQDSEASNSH KRGSSQGAFV
SEWSHQRIAV DEDEVNENDN LDEDDWKDMP ALGGFDVYDD YGRIVARGAP QEDDAAVYQG
LGGAGKGYTR VQIDEDAQSV TSLDDDTKYL FKEPESNAIG VEEEQRDPLA QLQATKDLLT
EGQRIAYVGV TRLMIYQMVK EVEAVHPSRS TKKYIVSAID SMAKWGQQMM IRLYTHMDID
SAEQIMIEQL AEHGVQPADL VPPLMRNSRI KNPMCSETTF RPSTSSAAAE DKPPSSSEIS
VTSEPRSSPS VLPPPYDYRG DEDSPNVKIP SEMPASESID IDIRWTVLCD LFLVLIADST
YDARSRRLLE RVGESLNVSW SQICRFEKRV IDALEMQEEK SKETWDEAEN MEARRKQALK
KRYMIMGLAT VGGGLVIGLS AGLLAPVIGA GLAAGFSTIG ITGTGAFLGG AGGTALIASG
ATLTGGTIAV RASHRRTGAV KTFEYRPLHN NKRVNLIVTV SGWMTGKVDD VRLPFSTVDP
IIGDIYSVLW EPEMLQSMGD TINILATEAL TQGLQQVLGS TILVALMASL QLPIVLTKLS
YLIDNPWNVS LVRANATGLI MADSIIARNL GNRPITLIGF SLGSRVIFSC LKELASKGAY
GLIQNVYLFG SPIVANKDEY MKARSVVSGR FVNGYASNDW ILGYLFRATS GGIMRVAGLA
PVENVPGIEN MDATQFVNGH MAYRAAMPKL LRQLGWEVES DEFTEIEDPD PDKHSERQRE
LIREIDEARK EAEAQPDKAR FGFFKRGKLA EKKGWETYDV DHKDHASRHS TESGVGSASD
HVLFDIDAIR AELESEQMEV KQLESTLPPI KIDLNAPSPL PRYSSNEKPS ASSETVSNTE
MRETDDYPYR LSSGTTSRSD IGRPRNSDEV NNDNHDNHED NIQMTFDTSY VSPPSYSPPA
LASSLSHDLS RDLSSRNLTP SPIPSQGASP RFGSINLNHN AWADDDYDER KDGDIKMTFG
//
