ID   C0NFM3_AJECG            Unreviewed;       722 AA.
AC   C0NFM3;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=XPG I-region protein {ECO:0000313|EMBL:EEH10044.1};
GN   ORFNames=HCBG_01689 {ECO:0000313|EMBL:EEH10044.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH10044.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family.
CC       {ECO:0000256|ARBA:ARBA00024023}.
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DR   EMBL; GG663364; EEH10044.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NFM3; -.
DR   STRING; 447093.C0NFM3; -.
DR   VEuPathDB; FungiDB:I7I50_00931; -.
DR   HOGENOM; CLU_378548_0_0_1; -.
DR   InParanoid; C0NFM3; -.
DR   OrthoDB; 6876at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd09902; H3TH_MKT1; 1.
DR   CDD; cd09858; PIN_MKT1; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR022039; MKT1_C.
DR   InterPro; IPR037314; MKT1_H3TH.
DR   InterPro; IPR022040; MKT1_N.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11081:SF32; POST-TRANSCRIPTIONAL REGULATOR MKT1; 1.
DR   Pfam; PF12246; MKT1_C; 1.
DR   Pfam; PF12247; MKT1_N; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT   DOMAIN          1..85
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00752"
FT   DOMAIN          313..401
FT                   /note="Post-transcriptional regulator MKT1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12247"
FT   DOMAIN          484..719
FT                   /note="Post-transcriptional regulator MKT1 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12246"
SQ   SEQUENCE   722 AA;  81442 MW;  BF9FD89EDC4F7983 CRC64;
     MPIRAFDEWA SSRAQTLPLA TLKGAVIGID ASHYLDQHLN HHATKEPLLI ALGGFPFSLR
     ANIEKEIQVL KNLGVTCVFV FNGLNFGKRE PDFTSQADST RALEQAWELY DQKQADQVVD
     AFSSAGSAKP ETLYKFLQRI LHEQGVDFLV APYAASAQLA YLEKGPNRFV DAVFGPSELF
     LFDIDKVITR LDTDVFRFTW ITRQVCQDDL GRITNEQFIE FCLLLGSRFL RTFPPFENAT
     FPGKGVNIRE AMTAYNNAGR NALVLCGQIE DEHRVNDLPY AESFKRALMT VKHHIIMDID
     GKVDPMDAEN VSNDLHELIG QRLPEELYFY MSKGILGSQV SDWLTSGELL IRLPLGAEDS
     DIYRRLQGEL LTPIRTQALC LLSNSLHRFY QTKAINVCTW YAPKSTRSIN LKEDLPSVKE
     STMSWKLRSD KFPESVKQLQ ADSLPFAFAL RALKDQEFVT KSFSTRDAPP LSSKSEILAN
     VMWRLLQLRG YVNDKHRLTQ WGQALEAAMS SLNPTENLEE STFIAVELLR LGILSSKDWF
     ANISGGPMRG TDEEKKFNLL VSQVACIGQI RHKSIGYSGP LSRQLLSFRS LICAVRSSLR
     DLVEVVLASL LLNGEADRDR DDWADLGLSL PFIDDNNCGL GIAVRTYLDD LPQQSEPTSP
     RVRAEVKSKG KEWFQHSDSF SGNLDLAFTL WDAAYQASQN AGKEFKDAKL WEEANKWLAE
     RR
//