ID C0NIK9_AJECG Unreviewed; 1105 AA.
AC C0NIK9;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DDENN domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCBG_02266 {ECO:0000313|EMBL:EEH08729.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH08729.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG663365; EEH08729.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NIK9; -.
DR VEuPathDB; FungiDB:I7I50_10887; -.
DR HOGENOM; CLU_001932_0_0_1; -.
DR InParanoid; C0NIK9; -.
DR OrthoDB; 1331806at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00029; C1; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR004146; DC1.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03107; C1_2; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 224..991
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 859..907
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 51..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 122520 MW; AFF6CEF9B59E7ADC CRC64;
MAPTPSAESP PSPLADFFWI AGVDGPEILD IFSKLGEEYH ANHTQSMPVT DTIQEDADAE
EAAHPRSGPS QPSSKRNSYQ LLPKPSDETR LSYRSMGSAE TPSNRSSMTI KGSQSPNGLS
FLSDGDFDKA LIKFAAERDS FLSDLSLSAG AVVSSNRPKP RPKTQKIVAE EVNPLKSSIG
SVRRHMSFRD MNSMKRQPSL ARQASIRTSR RLSNYNSVIP VPQPLDVSPN MHPLKRKFEP
VLLDRYPPKG VIDETKQRGN FPDYVPMFAF PNDINIVSSD QRPRSTWHGF AMTSGDGSKL
YGVCVTIWIP LHHKTAEELE KRCEEWRRDN MTDEERELAA SLGERLALER AKLSRLLSQL
PSVPSGSASR DQLEDDISSV EEKIGLMADL LRPVRLGAAT KIDGLTDGDT GFWIPRAYGI
LGKDGSMTSF WKEWLRAVVV PMTDGAVQRV PASSPRVGRW QPLERYVVNL CTEAFSPLFS
KTQVEISVRE LRLFARKEAI NELPGSRNTD LYALFRALSI SNIIILFEYV LAESRIILLS
SHAAMLYLAS KALVDLLFPF QWTGVFIPIL PARLIQALEA PCPYIVGIER RYDKAELPSD
DFVLVDLDQN EIESTARPTP LPRHHRRKLQ SLLQLAAPLH HRYGVHPGAP AYAIETYPFD
SFPGENQSIF SPRAPPTQLS KYVSVNSTAF GQDPSTSPAP PIFNVFLNSR NDVAFSRGYD
RPTTGVTSKA GTPPSPKASG DSSPTSSKFP PLPPTPISRN DSGFALQSSL REKRSGHFDA
SSRRSSSFGD RKHGIPRRPS APFLSHVSNL SVSTVNTDTG TSVYAPSIYA QSTVAASTIM
PNSSQQPLRN PVGTTLIEGH SLQLQQWDAN KVPCSICDEK AEEGMYKCSG CATIVHTRCA
SLITLVCPVA FSAEQVRAAF VRCFASLLYT YKKFLRPATG DKKKAGMHYT FNMDAFLKSL
PHEHAEYMTI LQQTQGFNEF IREREQSSLS SRDPRITLFD EIILSKRNRG RTSIFSGRMT
TNFLSDTSDH LWRSASATSI PSSRHQTNHS NDWKTTVARA PAKLDPNYMK EPRMIQGAPR
ISKTTNNARR KPVPRLPNDN GGSPP
//
