ID   C0NKW2_AJECG            Unreviewed;       827 AA.
AC   C0NKW2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=XPG-I domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HCBG_03792 {ECO:0000313|EMBL:EEH08503.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH08503.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG663366; EEH08503.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NKW2; -.
DR   STRING; 447093.C0NKW2; -.
DR   VEuPathDB; FungiDB:I7I50_07524; -.
DR   HOGENOM; CLU_007575_0_1_1; -.
DR   InParanoid; C0NKW2; -.
DR   OrthoDB; 1779469at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR   CDD; cd09906; H3TH_YEN1; 1.
DR   CDD; cd09870; PIN_YEN1; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR041177; GEN1_C.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   InterPro; IPR037316; Yen1_H3TH.
DR   PANTHER; PTHR11081:SF71; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   Pfam; PF18380; GEN1_C; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          1..101
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00485"
FT   DOMAIN          113..191
FT                   /note="XPG-I"
FT                   /evidence="ECO:0000259|SMART:SM00484"
FT   REGION          548..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          784..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  92308 MW;  91AC9BDE714FC9B0 CRC64;
     MGIPGLIQSL GPGERISLAK LAIDHLQRTS RPIRVAIDIS IWLFQVQAGK GGTNPELRTL
     FYRLVRLTGL PVHPLFIYDG PQRPQYKRGK LIDRNNRAGD LGRIIRRSKH LIDLFRFPHH
     TAPGEAEAEC ARLQTSGVVD AVMSDDVDAI MFGSKVTIMN FSKESSSGTN AATHVTLYQT
     EESGDGRKRN VLLDRGAMIL FALLSGGDYL PTGVPKCGPK LAGEIIQAGF GNELLQAIEG
     SPAEVAVKLE KWRERLRNEL HENGEGHFKC KHKAVKIPDC FPDLKVLGDY THPVVSSSEK
     LNELQRSFKW DQAIDIEGLR NFVWNDFGWQ RGSARRLTKV LAAPLVCNRL RLCLPLLAKP
     DALPLREPKI GTQFCGQRFH FSTDGLSELR LEFIPTDIVG LDLTYEPTTA SQRESESEDL
     DNPEIAEDVT NLKPGTRRRT TYDPTQKEKV WVFEAIAEMG MPDAVMTWNS QKQEKLALAE
     KRVSRKRAPK MTKPKVVDPK MKFGEILKYC TVVKSPGTGL IKFPSSSSQK HMHCDDSTIA
     NGYASELESP SSQACSPSKR NPIAKPRPSE KAALSDIEAT MNFERANESD QYNTSVETIE
     KAMLEMKISS DIGQSTPTKR GRIRRVSHKA ASLRAIPPTG TQTRNRNKSK DTSNIFPPVE
     NLDIERKSNP PKSNTIKSHS RLSISEYDLP TADDISSEFS GLKIQDCKVD EWSESSHTIA
     EGSGTSQNIP PAPTAAKLSS NDDRKELLFE TENSNHTSNS QVEVTELPVI EIYNGYWAYR
     QRKNNDEQDS PEVPSDNQGN LYNTQQKTIL DKKLGKMKLR GRILINL
//