ID   C0NQC2_AJECG            Unreviewed;       512 AA.
AC   C0NQC2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Monooxygenase {ECO:0000313|EMBL:EEH06394.1};
GN   ORFNames=HCBG_05710 {ECO:0000313|EMBL:EEH06394.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH06394.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; GG663369; EEH06394.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NQC2; -.
DR   STRING; 447093.C0NQC2; -.
DR   VEuPathDB; FungiDB:I7I50_03454; -.
DR   HOGENOM; CLU_009665_20_3_1; -.
DR   InParanoid; C0NQC2; -.
DR   OrthoDB; 1386239at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.2450; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR43004:SF6; FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Monooxygenase {ECO:0000313|EMBL:EEH06394.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          4..347
FT                   /note="FAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
SQ   SEQUENCE   512 AA;  56328 MW;  1EF1465B3EB341B8 CRC64;
     MNRIPVLIVG GGPSGLVLAS WLQRQNVGLR IIDKGEFRAS NSRAIVMHAR SLELYQKLGL
     ADEVIADGKQ MIAANLWIQG KHRVRLPIGD IGKGVTPYPF VHVYPQDRHE KLLEEKLAEA
     GITVERNREL VNFKDHGDHV SFTVLHNDTQ EREENCEAQY IIGCDGASST VRNGLSDIHF
     PGGTYQSRFY VADIEASGPA INGEVHVSLH SSDFLLIFAY NDSSRVRVVG MVDNKPDVPP
     ETLTFEDVSG TAIDSLKIKV EKVNWFSTYR VHHRVASKFR SGRAFLVGDA GHIHSPAGGQ
     GMNTGIGDAV NLAWKLAAVL QGHADPSLLD SFEEERIPFA RALIQRTDQA FSIATSGGFL
     ADIARSYIVP WILPVAMRLP GATDYAFRIL SQTHITYRGT SCVGGVAGHV HGGDRLPYTT
     PIGLDNYEAL SQIAWQVHVY GTPKEEMIAW CRDKDVALHA FDWTEDCKGV GFARDAAYLL
     RPDSYVAFAN LSGMLAQFEE YLGACGIRKL ST
//