ID   C0NTE4_AJECG            Unreviewed;       682 AA.
AC   C0NTE4;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Peptidase S8 and S53 {ECO:0000313|EMBL:EEH05305.1};
GN   ORFNames=HCBG_06424 {ECO:0000313|EMBL:EEH05305.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH05305.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG663371; EEH05305.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NTE4; -.
DR   STRING; 447093.C0NTE4; -.
DR   VEuPathDB; FungiDB:I7I50_05677; -.
DR   HOGENOM; CLU_011786_0_0_1; -.
DR   InParanoid; C0NTE4; -.
DR   OrthoDB; 1357839at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04842; Peptidases_S8_Kp43_protease; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034058; TagA/B/C/D_pept_dom.
DR   PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR   PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          219..548
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        228
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        265
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        487
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   682 AA;  73142 MW;  B93484C1B7091885 CRC64;
     MPSICINGNT LDPSAESRQL MDFGMIADDA SKSDYVLIQA SSDCLSTEEH GALQTLGVNI
     MEYVSEGTYL CSYKGTDLTQ IRSLEFISWA NTYCDQFVVQ GSLKSRTPQV KQLSAFTATP
     KTSHLQLVDI IVHHDVDPND DSVREAVAKA ARADLKCLEA TSQGFRLQVQ QEYLDDIAAI
     DQVYLIQQVH PFVLWNNKAR EIVGCSGTST YTEPGDYQGE GQVVVACDTG FDIGDKEDTH
     PAFTGRVDKL YDMGRKGKCD DPDGHGTHVA GSVLGNGESK SMGGSIMGTA PKAHLVLQSV
     LDGSNGLGGI PRDLTQLFRV PYEECGARIH TNSWGSASPF GQLPYDASAR QIDDFVWKHP
     DMVILFAGGN DGVDANRDGK IDQGQVGSQA SAKNIITVGA SENNRPDIPV TYGSRWPVDP
     LRNDRMADNP KGMAAFSSRG PTVEGRFKPD VVCPGTAVLS TLSRRAQMTS RFGQSSDPLW
     MFLAGTSMAT PLAAGCVACV RECLVKNGVK SPTAALLKAL ILHGAMELVG QYTPSEAGPS
     PNNSSGWGLL NLTNSICIAS GRGGGYLEGK ALGHGESAPT LTLTVPPNGT LKVTLVWTDP
     AGPRLQNDLD LSAIAPDGQE RHGNMSTGSG YDRVNNVEQI MWNNPPEGKM NISVKAFRIT
     RPSSPQPYAL VWSTTWPPDP KA
//