ID C0NTH0_AJECG Unreviewed; 593 AA.
AC C0NTH0;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Pre-mRNA-processing protein 45 {ECO:0000256|ARBA:ARBA00022160, ECO:0000256|RuleBase:RU367140};
GN ORFNames=HCBG_06450 {ECO:0000313|EMBL:EEH05331.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH05331.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing.
CC {ECO:0000256|RuleBase:RU367140}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|RuleBase:RU367140}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367140}.
CC -!- SIMILARITY: Belongs to the SNW family. {ECO:0000256|ARBA:ARBA00010197,
CC ECO:0000256|RuleBase:RU367140}.
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DR EMBL; GG663371; EEH05331.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NTH0; -.
DR STRING; 447093.C0NTH0; -.
DR VEuPathDB; FungiDB:I7I50_05649; -.
DR HOGENOM; CLU_006601_2_0_1; -.
DR InParanoid; C0NTH0; -.
DR OrthoDB; 5490078at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR017862; SKI-int_prot_SKIP.
DR InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR PANTHER; PTHR12096; NUCLEAR PROTEIN SKIP-RELATED; 1.
DR PANTHER; PTHR12096:SF0; SNW DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF02731; SKIP_SNW; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU367140};
KW mRNA splicing {ECO:0000256|RuleBase:RU367140};
KW Nucleus {ECO:0000256|RuleBase:RU367140};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Spliceosome {ECO:0000256|RuleBase:RU367140}.
FT DOMAIN 192..350
FT /note="SKI-interacting protein SKIP SNW"
FT /evidence="ECO:0000259|Pfam:PF02731"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 66170 MW; 5E43D5A1FFDEBB1C CRC64;
MATSIAQGLF KSLPKPKYTG EDEELPPHTQ PKGPRIVGAG AVNESQVVLK TAGPPPYGRR
SGWRPRNPED FADGGAFPEI PVAQYPLDMG RKGTSSTSNA LAVQVDAEGK VKYDAIAKQG
HGENRIVHAS FKDLIPLRQR VDMGEISLAR PSQEEVAEQM EKTKAALAKL VTGAVAAQKP
KNVKGGKRNE PTFVRYTPAN QMGDTSKKND RIMKIVERQV DPMEPPKFKH KKIPRGPPSP
PPPVMHSPPR KLTAEDQEAW RIPPPVSNWK NPRGYTVPLD KRLAADGRGL QDVSINDKFA
QFAEALFTAD RHAREEVKQR AQMQQKLAEK EKAQKEEHLR QLAQKAREAR SGGTSRQESR
ARTRSRSISG SRSPSPYSSR SATPSEDEDA ARERERRRRQ QRQEAERQLR QSRMGTERRI
QMMAREQNRD ISEKVALGLA KPTQSKETMY DSRLFNQTSG FESGFNEDQP YDKPLFAAQD
AINSIYRPRA QADDFDDEEA AGAEMSRIER NSRFEVLGRA KQGFKGAADA EARDGPVQFE
KDTSDPFGID GMIAEVTGGS TQKRYGIQEA EGAKERGSKR ARVDDDDDHD RGR
//
