ID C0NUI9_AJECG Unreviewed; 909 AA.
AC C0NUI9;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=DNA mismatch repair protein mutL {ECO:0000313|EMBL:EEH05069.1};
GN ORFNames=HCBG_07020 {ECO:0000313|EMBL:EEH05069.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH05069.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GG663372; EEH05069.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NUI9; -.
DR STRING; 447093.C0NUI9; -.
DR VEuPathDB; FungiDB:I7I50_12099; -.
DR HOGENOM; CLU_011171_2_0_1; -.
DR InParanoid; C0NUI9; -.
DR OrthoDB; 1369806at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT DOMAIN 202..353
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 359..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 100631 MW; 8A5362393B62B416 CRC64;
MSIAQLPPDT IRAVRSNSVL SDPCALAKEL IDNSLDAGAT CISVEVAANT LDTIQVKDNG
TGIHPNDRPL VCKRSCTSKL RSIDDLENIG GSTLGFRGEA LASAAEMCGN IAITTRVSGD
CTKASHPTGT TVRVYEFLRF VPVRKQRALK SASKTLNRMK KVLNAYVLSR PEIRLSFKIL
KSKHDSSWIY ASNKHPTVST AMLRVIGAEA ISQCTTITWP QIQDERDDSL PGSVERSESI
HPVIRLVATI PKPCSDFSSI NYAGQYVSID RRPMSTSNGV AKELAELFKS HIRSGSLCDS
GRTPPVDPFC FIHLHCRPGI YDVNVEPLKN DVLFEDSKLV MSIAGNIFKA VYGEIKPRHT
HQRNCQIENQ PSSSRMIRPL DKRSANNQRD HEVEESPLFR HISSSATKDC HSIERICASP
SEAKKDNMSA GSFVDTSACP RAAESNLSLL NSSLLTNPWM LAKGQPVTPR KEDTQSRDLN
SQLLTPAYED GRSRLDEKRI KNCEANSVLA GPPYPIPLST RTLETRLVEG DYDKSSTDVR
KPQMSELCNV PQLSASHKSK QRKSPGVLGS LDAWIRNCRD APSPSTEESQ VVGILQQSEP
DGNELTETDI AGRFGKEDNA AATSRSHGDF SAGLSPHTSL NALGIHLNSA HTNAKSHAQP
LAISQEEDDD PDYRIHGSTD NRLTSPSHEM VAGALDFEYR KKTAIQLHRK RQQQQQQQQQ
QQQQVSTQSA LHPWVGANNA KISQGSPHQN RYRRAKAHLV NQLPELEFPR HEITFSPSKM
GSEDAREYLM RQNWPTQIGF KSRRILTNQL PLEVIPSASA LHGLALSWTK QDDEASIPNK
ELLKIDGYVT SGIVPPPSAF FEVNPADINI WTTRLLALIQ EQYRSEILDE DWRIQLVFDA
IPTSHARAS
//
