ID   C0NWA5_AJECG            Unreviewed;       414 AA.
AC   C0NWA5;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN   ORFNames=HCBG_07435 {ECO:0000313|EMBL:EEH04210.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH04210.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00038048}.
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DR   EMBL; GG663374; EEH04210.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NWA5; -.
DR   STRING; 447093.C0NWA5; -.
DR   VEuPathDB; FungiDB:I7I50_07885; -.
DR   HOGENOM; CLU_031002_0_1_1; -.
DR   InParanoid; C0NWA5; -.
DR   OrthoDB; 5479972at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          9..139
FT                   /note="Saccharopine dehydrogenase NADP binding"
FT                   /evidence="ECO:0000259|Pfam:PF03435"
SQ   SEQUENCE   414 AA;  45747 MW;  5711D77222F3B8A7 CRC64;
     MTSPRHFDIV LLGATGYTGK LCAEHIVQNL PTNLTWAIAG RCVEKLSVLG EQLRKLDPER
     KEPEIVDLQL RPVELDSLAK RTKVILNCVG PYHLYSTPVV EACANNGTHY LDVTGEMPWV
     KEMIGKYHEK AKETGAIIIS ADGLECAPTD LLTWALVKYV SDKFSVHTKE VISSIYKLKT
     AGVSGGTFST VIGLVDKVPL KELYKAQNPY YLSASQHKRK YSSPFLQRVL GVRVVPELGT
     MTSYITGHCD VAVVHRSSSL MPELYGPHFH FESFVAVRNA LVGIILHIST IFGVLALTLP
     PVRWLVRKLI YAPGEGPEKR RTTGNRIEYR AIATAEERSA EGKPIKVLGT YKANCDAYGM
     TGVLLAESAM VLLTSERMSQ EIKGGYLTPA MLGQEYIDRL DKVGITIQMN VLEA
//