ID   C0NX66_AJECG            Unreviewed;       721 AA.
AC   C0NX66;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Biotin-[methylmalonyl-CoA-carboxytransferase] ligase {ECO:0000313|EMBL:EEH03932.1};
GN   ORFNames=HCBG_08058 {ECO:0000313|EMBL:EEH03932.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH03932.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   EMBL; GG663375; EEH03932.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NX66; -.
DR   STRING; 447093.C0NX66; -.
DR   VEuPathDB; FungiDB:I7I50_08317; -.
DR   HOGENOM; CLU_006150_1_1_1; -.
DR   InParanoid; C0NX66; -.
DR   OrthoDB; 317678at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd03144; GATase1_ScBLP_like; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR019197; Biotin-prot_ligase_N.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF09825; BPL_N; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 2.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EEH03932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          440..640
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   721 AA;  78641 MW;  F885E4CAF7AA9D4D CRC64;
     MTTNPVLLSK RLNVLVYSGA QTYSDWKTNI LTPAAPGNGT TVDAVRHCLY SLRRLLAANY
     AVIPVTGQMI VNEPWTASCA LLVMPGGADL PYCRTLNGEG NRRISQFVQR GGAYLGFCAG
     GYFASKRCEF EVGNKKLEVV GDRELAFFPG ICRGCAFPGF VYDSEDGARA AELKVSKSAQ
     AFGSVPEVFK AYYNGGGVFV DAPKYADQGV EVLASYTEDL SVDSGEGSAT VVYCKVGEGA
     AILTGAHPEF VFPAKPIDSW ELTKPRFAAS NLDRNADGPE YHKIVDVLAA DDESRVSFLK
     ACLTKLGLQV NQDSSTVPSL SRLHLSSLVP QGSAELISAL RDIITVTDGE EYIKDDIDTF
     HLEKPSSMGM RDIAESLPAG ISKTGQGGDS DTFLDYNSVI KEVVVHDETP SSKATPSFNH
     HAFYGNLKEY RSQSKEEIHE FGSNILYGEV VTSTSSLLEK NTQLLRRLPH GFVATATVQV
     AGRGRGSNVW VSPSGQLMFS IVIKHAVSNM TRAPVVFIQY IAAIAIAQGI KSYDKGYENM
     PIKLKWPNDI YALDPTKPDS KSYTKITGIL VNAHYSSAEY IAVVGIGINA LNPSPTTSLN
     ALLSSLAQKS PSNRSLPPLT LEKLLARILT AFESLYARFL RTGFDEHFFD LYYADWLHMD
     QIVTLEAEGG VRARIKGITS DYGLLVAEEL GWEDRPTGKT WELQSDSNSF DFFKGLIKRK
     V
//