ID C0NXM2_AJECG Unreviewed; 1085 AA.
AC C0NXM2;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=ATP-binding cassette protein {ECO:0000313|EMBL:EEH04088.1};
GN ORFNames=HCBG_08214 {ECO:0000313|EMBL:EEH04088.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH04088.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily.
CC {ECO:0000256|ARBA:ARBA00005814}.
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DR EMBL; GG663375; EEH04088.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NXM2; -.
DR STRING; 447093.C0NXM2; -.
DR VEuPathDB; FungiDB:I7I50_08534; -.
DR HOGENOM; CLU_000604_57_1_1; -.
DR InParanoid; C0NXM2; -.
DR OrthoDB; 359054at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03213; ABCG_EPDR; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR PANTHER; PTHR48041:SF139; PROTEIN SCARLET; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:EEH04088.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1085
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002901455"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 362..604
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 657..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1085 AA; 119758 MW; 51A78642E0B7F679 CRC64;
MRPPSLASSL LYASILASSS LPWLASAFSN YSDSSLLLSS RVLLQDDRPK DCPPCFNCEL
EAFQCHQFAA CNKYNGKCDC PAGFGGDDCT LPLCGSLPDG KERAPRKGKY CNCTEGWEGV
NCNVCKTDNV CNSMMPEGEG GVCYKDGVTQ KENYQMCAVT NRKIVDMLGD QKPEVTFSCK
ESDHKCNFQF WVDQVESFYC NLDTCKWGME STYSQNKTTY TCENKDALDL SDFLKEEIKG
PATFTSTSTL GGSSEDGSRF SEPVMNDMIK NIFGDPAIFL ACRSGECLYK TDLPGYKPPV
KVINTPLISG VIASCSLFIV AVIMGVWYLS RRSAYRDYIS LPLDDSDDEG AKLMVDHKPA
SLHFENVAYY LNGRQILSGI QGSAHPGQLM AIMGASGAGK TTFLDILARK NKRGTVEGVF
YVNGEKVDDD EYRSVIGFVD QEDTMLPTLT VHETIFTSAL LRLPRNMSRA AKEQKVFEVE
KQLGIYHIKD QIIGSEEGRG RGISGGEKRR VGIACELVTS PSILFLDEPT SGLDAFNAFN
VVECLVTLAK NFNRTVIFTI HQPRSNIVAL FDQLILLAEG KTVYSGPFAS CQPYFDHIGY
SCPSGFNIAD YLVDLTMHAS NTHSRYEDEI HLDVNHDAAR TATSSLRAVK SIASVSNASV
DNSSSDRPNE SGFRPISKRK ESLKQRQDKQ LYTRRRAAEV GTPSTLRTED EEHIVGSLSG
NGQHRSRQPN NVTLRVIDDP DQPPPSSAGF GTDLDHLVSS YIESNVAASV RDEINAAVNM
AAEANGFTSS GLEANGSLNK SMTGYAKVGL YRQFTILSQR TWRNLYRNPM LMLTHYAIAI
VLAVLSGFLF YGLTDDIKGF QNRLGLFFFL LALFGFSTLT SLNVFSTERL LFVRERANGY
YSPITYFASK VAFDIVPLRL IPPILMGIIV YPMVGLIPAW PEFLRFMLIL LLFNLAAACI
CLTIGIVFKD SSVANLMGSL VMLFSLLFAG LLLNRDAIPK SALWLQVLSI FHYGFEGLIV
NEVTYLTLID HKYGLDIEVP GASILSAFGF NTLGLWHDVI GLGIFSGVFI VIAYAAMHFL
LVEKR
//
