ID   C0NXQ5_AJECG            Unreviewed;       296 AA.
AC   C0NXQ5;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:EEH03573.1};
GN   ORFNames=HCBG_07699 {ECO:0000313|EMBL:EEH03573.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH03573.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG663376; EEH03573.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NXQ5; -.
DR   STRING; 447093.C0NXQ5; -.
DR   HOGENOM; CLU_051938_2_0_1; -.
DR   InParanoid; C0NXQ5; -.
DR   OrthoDB; 517134at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005645; FSH-like_dom.
DR   PANTHER; PTHR48070; ESTERASE OVCA2; 1.
DR   PANTHER; PTHR48070:SF6; ESTERASE OVCA2; 1.
DR   Pfam; PF03959; FSH1; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          12..266
FT                   /note="Serine hydrolase"
FT                   /evidence="ECO:0000259|Pfam:PF03959"
SQ   SEQUENCE   296 AA;  32496 MW;  3502CF9D856CD78F CRC64;
     MAPQTPTHPK APLKILMLHG YTQSGPLFHA KTRALEKHLK KSFPLHSVSL SYPTGPLHLS
     PSDIPDFQPF STPSAEANDT DQPECFAWWR RSNTANPPEY QGLDEGLETI ARVLADEGTF
     DGVIGFSQGA AFAAMVASLL EPGRKGSFEY FADMANHESS ISSSSAGDPV TGIPFPTSFD
     KLTHPPFKFA ICYSGFIAPG ARYRAFYDRP RIQTPVLHVL GSLDGIVEED RSRMLIGACA
     GDAEKEGKVI WHPGGHFLPS QRPYLDGAVN FVRECLEKQT VDGLIEEKVE DMEMPF
//