ID   C0P0M8_AJECG            Unreviewed;       672 AA.
AC   C0P0M8;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Beta-galactosidase/beta-glucuronidase {ECO:0000313|EMBL:EEH02848.1};
GN   ORFNames=HCBG_08958 {ECO:0000313|EMBL:EEH02848.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH02848.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
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DR   EMBL; GG663381; EEH02848.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0P0M8; -.
DR   STRING; 447093.C0P0M8; -.
DR   VEuPathDB; FungiDB:I7I50_05296; -.
DR   HOGENOM; CLU_009935_2_1_1; -.
DR   InParanoid; C0P0M8; -.
DR   OrthoDB; 19834at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR42732:SF3; BETA-MANNOSIDASE; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT   DOMAIN          21..204
FT                   /note="Glycosyl hydrolases family 2 sugar binding"
FT                   /evidence="ECO:0000259|Pfam:PF02837"
FT   DOMAIN          304..342
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   DOMAIN          381..522
FT                   /note="Glycoside hydrolase family 2 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02836"
SQ   SEQUENCE   672 AA;  75481 MW;  1E52C2EE4797E24F CRC64;
     MASSVQEYPR PDFARSDLNW KSLNGPWSFL YDDDDSGILD GWHLRGLPEQ IAVTAGQNSG
     AGKTLQKLEI TVPYVFQTPA SGIGEREPHE VIWYERLVDD IRTPAELKKH FRLLLRFGAV
     DYEATIWLDG QYVGEHRGGH VPFDLDLSEF IKAQQQSARL TIRVRDSPYD LTQPRGKQYW
     AGKPQGIWYT PSSGIWQSVW LESVPRARIA DSSGGTVLRS NDIYGGLLHA TISLVGRRAW
     RKYHVKLQIS IGGVTVDKTS QISIPQHSNV VDCAVRAKLS REQLGKLPSG LLEGAPLEDH
     TAWLDGVALW SPDHPLLYDV VLSLFDGGGT LLDEVQTKIG MRELNWTTGD HTFRLNGHPI
     FQALVLDQGY WPETGMTPPS AEALKHDIEL AQSMGFNGCR KHQKVEDPRF LYFADQLGFL
     VWGEMANGYE FSNAYVDRFN EEWMAAVKRD INHPSIVTWT PINESWGYPE LKDNVQQQNH
     IRSLYYMTKC LDPTRSVNDN CGWEHVCDDL TTFHDYSDGP ALTTICKTVE GILDKKGGRH
     TFVGGSRHRK GAPIMCTEFG GVNIAPSDPN VKGDGDWGYT TASDPADLLA RLEKLLMGVV
     GGGHCCGFVY TQIVDVEQEV NGLYTFDRKA KLKPELVEDI NRRAKKLYLE SVDPKGLSRH
     LRTFKHMVQG KV
//