ID C0PCY4_MAIZE Unreviewed; 257 AA.
AC C0PCY4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=PHD finger protein ALFIN-LIKE {ECO:0000256|RuleBase:RU369089};
GN Name=ALF13 {ECO:0000313|EMBL:AIB05811.1};
GN Synonyms=100284916 {ECO:0000313|EnsemblPlants:Zm00001eb145370_P004};
GN ORFNames=ZEAMMB73_Zm00001d042582 {ECO:0000313|EMBL:ONM35803.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ACN32029.1};
RN [1] {ECO:0000313|EMBL:ACN32029.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B73 {ECO:0000313|EMBL:ACN32029.1};
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [2] {ECO:0000313|EMBL:AIB05811.1}
RP NUCLEOTIDE SEQUENCE.
RA Burdo B., Gray J., Goetting-Minesky M.P., Wittler B., Hunt M., Li T.,
RA Velliquette D., Thomas J., Gentzel I., Dos Santos Brito M.,
RA Mejia-Guerra M.K., Connolly L.N., Qaisi D., Li W., Casas M.I., Doseff A.I.,
RA Grotewold E.;
RT "The Maize TFome - Development of a transcription factor open reading frame
RT collection for functional genomics.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ONM35803.1, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb145370_P004,
RC ECO:0000313|Proteomes:UP000007305};
RC TISSUE=Seedling {ECO:0000313|EMBL:ONM35803.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblPlants:Zm00001eb145370_P004}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb145370_P004};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC start sites of virtually all active genes.
CC {ECO:0000256|ARBA:ARBA00002232, ECO:0000256|RuleBase:RU369089}.
CC -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369089}.
CC -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SIMILARITY: Belongs to the Alfin family.
CC {ECO:0000256|ARBA:ARBA00010445, ECO:0000256|RuleBase:RU369089}.
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DR EMBL; BT066153; ACN32029.1; -; mRNA.
DR EMBL; KJ728320; AIB05811.1; -; mRNA.
DR EMBL; CM007649; ONM35803.1; -; Genomic_DNA.
DR RefSeq; XP_008672987.1; XM_008674765.1.
DR AlphaFoldDB; C0PCY4; -.
DR SMR; C0PCY4; -.
DR IntAct; C0PCY4; 1.
DR STRING; 4577.C0PCY4; -.
DR PaxDb; 4577-GRMZM2G080917_P01; -.
DR EnsemblPlants; Zm00001eb145370_T004; Zm00001eb145370_P004; Zm00001eb145370.
DR GeneID; 100284916; -.
DR Gramene; Zm00001eb145370_T004; Zm00001eb145370_P004; Zm00001eb145370.
DR eggNOG; KOG1632; Eukaryota.
DR HOGENOM; CLU_058315_0_0_1; -.
DR InParanoid; C0PCY4; -.
DR OrthoDB; 313735at2759; -.
DR Proteomes; UP000007305; Chromosome 3.
DR ExpressionAtlas; C0PCY4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd15613; PHD_AL_plant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045104; Alfin.
DR InterPro; IPR021998; Alfin_N.
DR InterPro; IPR044104; PHD_AL_plant.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12321; CPG BINDING PROTEIN; 1.
DR PANTHER; PTHR12321:SF77; PHD FINGER PROTEIN ALFIN-LIKE 6; 1.
DR Pfam; PF12165; Alfin; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator {ECO:0000256|RuleBase:RU369089};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369089}; Nucleus {ECO:0000256|RuleBase:RU369089};
KW Proteomics identification {ECO:0007829|PeptideAtlas:C0PCY4};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU369089};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU369089};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU369089};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 201..253
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 148..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 28822 MW; F7BF5DF9B49250E0 CRC64;
MDGGGSGPAP NAAHTAEEVF RDYKARRAGM IKALTTDVER FFKLCDPEKE NLCLYGYPDE
TWEVTLPAEE VPPEIPEPAL GINFARDGMN EKDWLALVAV HSDSWLLSVA FYFGARFGFD
REARRRLFSL INNMPTIFEV VTGAVKKQQA KEKTPNSSSK SNKPSSKVQS RAESRSKAKV
PKDEEESGDD DGDEEAEEHD NTLCGTCGTN DGKDQFWICC DNCEKWYHGK CVKITPARAE
HIKQYKCPDC TNKRVRA
//
