ID C0QAM2_DESAH Unreviewed; 560 AA.
AC C0QAM2;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Fe-S oxidoreductase family protein {ECO:0000313|EMBL:ACN16805.1};
GN OrderedLocusNames=HRM2_37470 {ECO:0000313|EMBL:ACN16805.1};
OS Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 /
OS HRM2) (Desulfobacterium autotrophicum).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulforapulum.
OX NCBI_TaxID=177437 {ECO:0000313|EMBL:ACN16805.1, ECO:0000313|Proteomes:UP000000442};
RN [1] {ECO:0000313|EMBL:ACN16805.1, ECO:0000313|Proteomes:UP000000442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43914 / DSM 3382 / HRM2
RC {ECO:0000313|Proteomes:UP000000442};
RX PubMed=19187283; DOI=10.1111/j.1462-2920.2008.01825.x;
RA Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S.,
RA Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A.,
RA Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O.,
RA Meyerdierks A., Gottschalk G., Amann R.;
RT "Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate
RT reducer oxidizing organic carbon completely to carbon dioxide.";
RL Environ. Microbiol. 11:1038-1055(2009).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001087; ACN16805.1; -; Genomic_DNA.
DR RefSeq; WP_015905551.1; NC_012108.1.
DR AlphaFoldDB; C0QAM2; -.
DR STRING; 177437.HRM2_37470; -.
DR KEGG; dat:HRM2_37470; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_4_7; -.
DR OrthoDB; 9804952at2; -.
DR Proteomes; UP000000442; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF17; MG-PROTOPORPHYRIN IX MONOMETHYL ESTER OXIDATIVE CYCLASE 66KD SUBUNIT; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000000442}.
FT DOMAIN 8..143
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 178..418
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 560 AA; 63434 MW; B494047B90B0A98A CRC64;
MTVLLVNPAC LDPRVTDGDA LLVPMGLFYI AALLNENRIP TQVVNLAVEE NPLDHLRSRV
IAERPRIVGF SVLNANRFSA MEGAKVVKDV DPEILVVFGG PCATFLCDHL FSLCPELDYV
VKGEGEITFL ELAEHLQRDE KHPAAMVQGL AHRGGLGKIV HTPERRPIED LDSLPIPGRY
FDFQHVSLSR GCPGHCTFCG SPRFWPGARV RFHSPEWFVA QLSLLEKRGI NHFFVSDDTF
TMDKTRVIKV CRIIIEQELP ITWVAISRVD FIDSEILLWM RRAGCTQISF GVESGSADIR
KRLGKPMDRE RIVKAFALTV SYGIMPRAYF IYGSPGETDK TIRESLDLIM EIRPLSAIFY
LLVLFPGTHL YQRLVDQGRL SDQLWSRKIE DLPWFEMDPD LDFDRVKTFG HALRKGFYSN
LSDFAAGIEL VDEKSLYPLH ADFLSRLALT FSHGEYAQNP WVKKPMDTAQ LLFERALGYH
PDHRAFLGLA MLFQKLRQFD SAIATATAGL RHFKSSRDLN ICMAVSLMNL GRFQDALGFL
EPFKDNPEVK VYVDACIGRI
//
