ID C0QHY8_DESAH Unreviewed; 534 AA.
AC C0QHY8;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Alkaline serine protease (Subtilase family protein) {ECO:0000313|EMBL:ACN15724.1};
DE EC=3.4.21.75 {ECO:0000313|EMBL:ACN15724.1};
GN OrderedLocusNames=HRM2_26300 {ECO:0000313|EMBL:ACN15724.1};
OS Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 /
OS HRM2) (Desulfobacterium autotrophicum).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulforapulum.
OX NCBI_TaxID=177437 {ECO:0000313|EMBL:ACN15724.1, ECO:0000313|Proteomes:UP000000442};
RN [1] {ECO:0000313|EMBL:ACN15724.1, ECO:0000313|Proteomes:UP000000442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43914 / DSM 3382 / HRM2
RC {ECO:0000313|Proteomes:UP000000442};
RX PubMed=19187283; DOI=10.1111/j.1462-2920.2008.01825.x;
RA Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S.,
RA Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A.,
RA Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O.,
RA Meyerdierks A., Gottschalk G., Amann R.;
RT "Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate
RT reducer oxidizing organic carbon completely to carbon dioxide.";
RL Environ. Microbiol. 11:1038-1055(2009).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP001087; ACN15724.1; -; Genomic_DNA.
DR RefSeq; WP_015904487.1; NC_012108.1.
DR AlphaFoldDB; C0QHY8; -.
DR STRING; 177437.HRM2_26300; -.
DR KEGG; dat:HRM2_26300; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_011263_9_0_7; -.
DR Proteomes; UP000000442; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07484; Peptidases_S8_Thermitase_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034084; Thermitase-like_dom.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF17957; Big_7; 2.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000000442};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 88..329
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 94
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 127
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 281
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 534 AA; 56596 MW; A2460B1249CE1B90 CRC64;
MDKLLHSHGA ATAGEIENIR VHRITVPEHA LEQVKKALSK NPNIQFVEEN FIAESGYVPN
DERYSSQWHL PMISAPDGWD LTTGSPSVPI AIIDSGVDST HPDLAGNLIA GYNFLENNTD
TQDVLGHGTA VAGSAAAITD NITGVAGVAG DSPIMPLVIL DANDYATYYD IARAMNYAAD
QGVRIINISI GGSSYSSTLQ NAVNYAWNKG AAIFARAHNY STDTPYYPAA CANVVAVSAT
TSSDTLASFS NYGDWIDISA PGAYILTTTR GGGYGNWNGT SFSSPITAGV AALILSANPS
LTNAQVVDIL TQSADALGST RFDTYFGYGR VNALESILTA LGAAPDEDTI DPSVAITSPQ
NDTTVNGSLT VSVSAADERG VDRVELYVDG ELFDEDITSP YSFFWDTTTD ANDTYELVAV
AYDTAGNSGQ SGVISVSVDN VIFKDTGALI VTISSHKDGA SIGDLEKVQA SASDDSGISR
MELFLDGELK AVKYKSELRW NWNTRKLSKG AYTFSVKAFD TAGNEGIETI TVYK
//
