ID C0QS32_PERMH Unreviewed; 616 AA.
AC C0QS32;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=citrate synthase (unknown stereospecificity) {ECO:0000256|ARBA:ARBA00012972};
DE EC=2.3.3.16 {ECO:0000256|ARBA:ARBA00012972};
GN OrderedLocusNames=PERMA_1714 {ECO:0000313|EMBL:ACO04502.1};
OS Persephonella marina (strain DSM 14350 / EX-H1).
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=123214 {ECO:0000313|EMBL:ACO04502.1, ECO:0000313|Proteomes:UP000001366};
RN [1] {ECO:0000313|EMBL:ACO04502.1, ECO:0000313|Proteomes:UP000001366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14350 / EX-H1 {ECO:0000313|Proteomes:UP000001366};
RX PubMed=19136599; DOI=10.1128/JB.01645-08;
RA Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001230; ACO04502.1; -; Genomic_DNA.
DR RefSeq; WP_012676740.1; NC_012440.1.
DR AlphaFoldDB; C0QS32; -.
DR STRING; 123214.PERMA_1714; -.
DR PaxDb; 123214-PERMA_1714; -.
DR KEGG; pmx:PERMA_1714; -.
DR eggNOG; COG0074; Bacteria.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_006587_4_1_0; -.
DR OrthoDB; 9759263at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000001366; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003878; F:ATP citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06100; CCL_ACL-C; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005811; SUCC_ACL_C.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR23118; ATP-CITRATE SYNTHASE; 1.
DR PANTHER; PTHR23118:SF42; ATP-CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PRINTS; PR01798; SCOASYNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:ACO04502.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lyase {ECO:0000313|EMBL:ACO04502.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001366};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACO04502.1}.
FT DOMAIN 176..299
FT /note="ATP-citrate synthase/succinyl-CoA ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00549"
SQ SEQUENCE 616 AA; 67957 MW; B1813F807325ECAF CRC64;
MSKPDYLLFD RNTKAIFWNL NRNAIQRMLD YDYVVGRDPS IVAIVAPTQS RKFDKFFYGT
QEIMIPIYKS TPEAAEDFPE ADVLLNFASF RTAYDVTMEA LDIPTIRTIA ITAEGIPERF
ARIMRIKAKE LGKWIIGPAT VGGIAPGAFR IANTGGTIEN IVNSKLHRPG SVGLVTRSGG
LFNELSNVIA RNANGIAEGI AIGGDRYPGT DFLDHMLRFE KNPQVKMMVL LGEVGGELEY
RVAEAIKDGR ITKPVIAWCI GTISKYFGGE VQFGHAGAKA GAERETADAK NEALREAGAY
VPKSFNDLPE LINGVYEELH SKGEIADIPE PEVPPVPEDY AKAVKAGKVR RPTNFICTIS
DDRGEEATYC GVPISEVVEK NYSIADVIGL LWFKQKFPDW ASKFLDMVIK VVADHGPAVS
GAHNTKVTAR AGKDLMSSIV TGILTIGPRF GGAIDGAAKY FKMAKEKGMD PVDFVDYMKK
VEKIPIPGIG HRIKSTKNPD KRVELLKNFA KENFPSTELL DYALEVEKVT TSKKENLILN
VDGTIGVLLV DMFRALGYSD EQIDELINAG AFNAFFVLGR TIGFIGHYLD EKRLDMPLYR
HPTDDILYDV KRPEGA
//
