ID C0QUE6_PERMH Unreviewed; 292 AA.
AC C0QUE6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|RuleBase:RU361259};
GN Name=galU {ECO:0000313|EMBL:ACO04658.1};
GN OrderedLocusNames=PERMA_0522 {ECO:0000313|EMBL:ACO04658.1};
OS Persephonella marina (strain DSM 14350 / EX-H1).
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=123214 {ECO:0000313|EMBL:ACO04658.1, ECO:0000313|Proteomes:UP000001366};
RN [1] {ECO:0000313|EMBL:ACO04658.1, ECO:0000313|Proteomes:UP000001366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14350 / EX-H1 {ECO:0000313|Proteomes:UP000001366};
RX PubMed=19136599; DOI=10.1128/JB.01645-08;
RA Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872,
CC ECO:0000256|RuleBase:RU361259};
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890, ECO:0000256|RuleBase:RU361259}.
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DR EMBL; CP001230; ACO04658.1; -; Genomic_DNA.
DR RefSeq; WP_012676895.1; NC_012440.1.
DR AlphaFoldDB; C0QUE6; -.
DR STRING; 123214.PERMA_0522; -.
DR PaxDb; 123214-PERMA_0522; -.
DR KEGG; pmx:PERMA_0522; -.
DR eggNOG; COG1210; Bacteria.
DR HOGENOM; CLU_029499_1_2_0; -.
DR OrthoDB; 9803871at2; -.
DR Proteomes; UP000001366; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01099; galU; 1.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU361259,
KW ECO:0000313|EMBL:ACO04658.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001366};
KW Transferase {ECO:0000256|RuleBase:RU361259, ECO:0000313|EMBL:ACO04658.1}.
FT DOMAIN 6..266
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 292 AA; 32839 MW; 05CF83F2BB8842CF CRC64;
MLQVKKAVIP VAGFGTRFLP ATKATPKEMM PIVDKPIIQY IVEEAVKSGI DTIIFVTGRH
KRAIEDHFDY APELEYTLEK SGKDEYVNII REISDMANFV YIRQKEQLGL GHAILTAQHV
IGNEPFAVLL GDELIINEEQ PGIKQLIEVY QKFGKSVLGT TEVPKEETYK YGIVEGTEIE
DGIKLVNYLV EKPEPEEAPS TSAIIGRYIL TPNIFDALKR TPFGKGGELQ LTDALMTLRK
EEAVYAKDIE GIRHDTGNKL GYIKAIIDFA LEREDTKDFI KQLIISKAKE LQ
//
