ID C0W030_9ACTO Unreviewed; 997 AA.
AC C0W030;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=HMPREF0044_0908 {ECO:0000313|EMBL:EEH63889.1};
OS Gleimia coleocanis DSM 15436.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Gleimia.
OX NCBI_TaxID=525245 {ECO:0000313|EMBL:EEH63889.1, ECO:0000313|Proteomes:UP000010301};
RN [1] {ECO:0000313|EMBL:EEH63889.1, ECO:0000313|Proteomes:UP000010301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15436 {ECO:0000313|EMBL:EEH63889.1,
RC ECO:0000313|Proteomes:UP000010301};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEH63889.1}.
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DR EMBL; ACFG01000030; EEH63889.1; -; Genomic_DNA.
DR RefSeq; WP_006546680.1; NZ_DS999543.1.
DR AlphaFoldDB; C0W030; -.
DR STRING; 525245.HMPREF0044_0908; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_11; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000010301; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000010301}.
FT DOMAIN 714..983
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 997 AA; 113355 MW; 9C5046FEB73BA32D CRC64;
MNNWENPQLQ HENRLKPHAY MRPHATQADA TAAQCPANAY ADRSRISDYQ NLDGTWNFSF
YTHPERVPAD FTSRILTTDT VTIPHMWQLD GYGNLQYTDE GFPFPIDVPF VPAENPTGIY
QKTITLPEKD PARHYHIVFD GVESYFEIYL NGHYLGFSKG SRLTAEFDLT STIQSGENLL
VVKVLQFSDG TYIEDQDMWW ASGIFRSVWM LSRPTTYLHD FYAVTKLVDV NTALVNISAE
LNQLSATTAL KIEVLDKEKL LNSTTLNFTS TQATTQLRLE NIHTWNPEAP YLYTLRFTLL
DENKPTEVIE HLLGLKEITI TNGKLYLNGQ YFKMHGVNRH DFEPRKGRAI SMERAQRDVE
LMKEHNINSV RTAHYPNDPR FYEMCDRLGL LVVAETDLES HGFENIGKLN TLTDDPAWEY
AYVDRIERHV LAQRNHASIL LWSLGNESGY GCNIGTMYRR CKELDPTHPV HYEEDRNAEY
VDVISTMYSR VSQMNDFGEY PHPKPRIICE YGHAMGNGPG GLAEYQEVFN RWDSIQGHFV
WEWCDHGLQL PGDDTYHYGG DFGDYPNNAN FCIDGLIFPW QEPSPGLTQY KFLLSPLKLS
YQEGSLRVKS MLWFTEATDF QLSYRWLLNG VEVSDGIVDV PVLSVGAETE ITLPAPEVSA
GELSLAVHVL RAGFAEPVGL GSWVIRERDY ADTPVPGAGE FRTDFSEGVL RISTIANNWV
AEFDTVSGQL TSLVYNNSEV FAQPLSLGFW KPLIDNHQQE FDSIWKPKHL QIMQRHARNC
EWRVSGQQLV VVVREQIAPP VFNFGMRAEL TYTFELDGSF RVRFTGSPYG DYRNIVPRVG
LSCALPAGFE SVEYYGYGPG ENYSDSHAAA YLGCFTAEVA DFYTPYVVPQ DHGNRWQTRW
AAVSDGTVGL RVEAVVPFNF RVSEYSDEML DTTSHSSSLE KSGLTHLHVN PQLLGLGSNS
WGSEVLHSHR CFFAEFAHEV KFIPFAVENQ TPVEVAL
//
