ID C0W2F6_9ACTO Unreviewed; 658 AA.
AC C0W2F6;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Xanthine permease {ECO:0000313|EMBL:EEH67059.1};
GN Name=pbuX {ECO:0000313|EMBL:EEH67059.1};
GN ORFNames=HMPREF0058_0050 {ECO:0000313|EMBL:EEH67059.1};
OS Actinomyces urogenitalis DSM 15434.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=525246 {ECO:0000313|EMBL:EEH67059.1, ECO:0000313|Proteomes:UP000004778};
RN [1] {ECO:0000313|EMBL:EEH67059.1, ECO:0000313|Proteomes:UP000004778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15434 {ECO:0000313|EMBL:EEH67059.1,
RC ECO:0000313|Proteomes:UP000004778};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEH67059.1}.
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DR EMBL; ACFH01000004; EEH67059.1; -; Genomic_DNA.
DR RefSeq; WP_006549350.1; NZ_DS999576.1.
DR AlphaFoldDB; C0W2F6; -.
DR STRING; 103621.GCA_001067145_01345; -.
DR GeneID; 81707858; -.
DR eggNOG; COG2233; Bacteria.
DR eggNOG; COG3195; Bacteria.
DR HOGENOM; CLU_017959_8_2_11; -.
DR OrthoDB; 9805749at2; -.
DR Proteomes; UP000004778; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000004778};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 41..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..636
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 69059 MW; E7240160EE5194B4 CRC64;
MSYGQPPSVA DPVSSSPRPK DPVDAVPPFG RLAVLGVQHV LAFYAGAVVV PLVIASGLNL
DAATTVHLIN ADLLTCGIAT IIQSAGLGPK IGVRLPLIQG VTFTAVSPLI AIGLAASGGA
GGTQGLTAMY GSIIAAGLAT FLVAPWFARL LRFFPPVVTG TLLTVMGTTL MSVSAGDIVA
WGTQASAAGA DPAGPTLRGL GYAMLTIALI VLVQRVFKGF MSTISVLIGL VVATGLAWVL
GDTDFSGVGE AAVVGITTPF YFGIPTFTVT GIVSMLIVMA VTAVETTGDV FATGEVVGKR
ITPTHVANAL RADGLSTMLG GVLNSFPYTC FAQNVGLVRL TRVRSRWVVT CAGVIMIVLG
LLPKAAAVVA AIPSPVIGGA SLAMFASVAV VGIQTLGKVD MHDNRNAVIV STSMGLALLV
TFKPDIASMM PSWLAILFGS GVTIGALTAV ILNLLFFHLD RQDGADVALV HGRAVGLDEV
NEMEREQFVE VFSRLYADAT WPAERAWEHR PFASTAALRQ AFEDEVLSAQ PQEQEALIRG
YADITELLLG EDGNTQAELD TASLALGSFN DAEEAELRGL SQAYQEKFSR PLVMCVERLT
DRHQLLARGW ARVESSPARE ARCAVGEVID IADERFDAMV ADANPIRSAW SRKFEQLD
//
