ID C0W6H5_9ACTO Unreviewed; 667 AA.
AC C0W6H5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Succinate dehydrogenase or fumarate reductase, flavoprotein subunit {ECO:0000313|EMBL:EEH65668.1};
DE EC=1.3.99.1 {ECO:0000313|EMBL:EEH65668.1};
GN Name=sdhA {ECO:0000313|EMBL:EEH65668.1};
GN ORFNames=HMPREF0058_1469 {ECO:0000313|EMBL:EEH65668.1};
OS Actinomyces urogenitalis DSM 15434.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=525246 {ECO:0000313|EMBL:EEH65668.1, ECO:0000313|Proteomes:UP000004778};
RN [1] {ECO:0000313|EMBL:EEH65668.1, ECO:0000313|Proteomes:UP000004778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15434 {ECO:0000313|EMBL:EEH65668.1,
RC ECO:0000313|Proteomes:UP000004778};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEH65668.1}.
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DR EMBL; ACFH01000108; EEH65668.1; -; Genomic_DNA.
DR AlphaFoldDB; C0W6H5; -.
DR STRING; 103621.GCA_001067145_01071; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_11; -.
DR Proteomes; UP000004778; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEH65668.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004778}.
FT DOMAIN 50..470
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 533..666
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT ACT_SITE 346
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 667 AA; 75145 MW; AEB5598BE8138D4A CRC64;
MMTELIEGLY TEGEKIADTK APHDVPIAKR WEQRKFNAKL VNPANRRKLD IIVVGSGLAG
GAAAASLGEQ GYNVKCFFYQ DSARRAHSIA AQGGINAAKN YRNDGDSIYR LFYDTVKGGD
YRAREDNVYR LAEVSANIID QCVAQGVPFA REYGGLLDNR SFGGVQVSRT FYARGQTGQQ
LLIGAYQALE RQVRAGTVKE FRRHEMVELI VVDGKAKGII ARDMVTGKIE THLADAVVLC
TGGYGNVFFL STNAMGCNAT AIWRAHRKGA YFANPCYTQI HPTCIPQSGD FQSKLTLMSE
SLRNDGRIWV PKKAEDCKKD PKDIPEEDRD YYLERIYPAF GNLVPRDIAS RQAKNMCDEG
RGVGPAIKEK APDGTERMVS RGVYLDFSEA IERLGKEQVS AKYGNLFEMY QRITGDDPYE
TPMRIYPAVH YTMGGLWVDY DLESNIPGLY VAGEANFSDH GANRLGASAL MQGLADGYFV
LPDTMNDYLA DMLREGKVDP NAPEIEEARK SVEERISRLM ALRGTRSVDD FHMALGRIMW
EYCGMERRDE GLREAIKQIR ELKEEFWRDA RITGEAMELN QTLEKAGRLL DFFELAELMC
IDALHRRESC GGHFRAESQT PEGEALRHDD EFLYVAAWEW GGENQAPILH KEDLIYKDIE
LKQRSYK
//
