ID C0Z5R8_BREBN Unreviewed; 3180 AA.
AC C0Z5R8;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:BAH46174.1};
GN OrderedLocusNames=BBR47_51970 {ECO:0000313|EMBL:BAH46174.1};
OS Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599).
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=358681 {ECO:0000313|EMBL:BAH46174.1, ECO:0000313|Proteomes:UP000001877};
RN [1] {ECO:0000313|EMBL:BAH46174.1, ECO:0000313|Proteomes:UP000001877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47 / JCM 6285 / NBRC 100599
RC {ECO:0000313|Proteomes:UP000001877};
RA Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W.,
RA Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S.,
RA Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.,
RA Udaka S., Tanikawa S., Fujita N.;
RT "Brevibacillus brevis strain 47, complete genome.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; AP008955; BAH46174.1; -; Genomic_DNA.
DR RefSeq; WP_015893427.1; NC_012491.1.
DR STRING; 358681.BBR47_51970; -.
DR KEGG; bbe:BBR47_51970; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_0_9; -.
DR OMA; VDSICEI; -.
DR Proteomes; UP000001877; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001877}.
FT DOMAIN 505..580
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1560..1637
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2623..2698
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3180 AA; 360635 MW; 457B9ACAD3D8026F CRC64;
MQDSITALLE EQVELHPDAI ALVYKDATLT YKELNSRANQ LAHYLQSSGV GAESRVGLYM
DRSFEMIISM VAILKAGGAY VPLDPAYPEQ RLLYMLQDAS ISIVLTQESM VSRLPDGLKI
VCPDLDVSKI NKESDANVGG STTSESLAYL MYTSGSTGNP KGVLIPHRGV IRLTKHASYV
TLTPKETMLQ LASISFDAAT FEIWGSLLNG AKLVIYPFPG LSLEELGQVL REEKISTLWL
TAGVFHQMID YRIEDLKGVR QLLTGGDIVS AKHAQRALDM LPETLVINGY GPTENTTFTC
FYHITQKSEI QHSVPIGRPI NDTEVFILND KQKLVPVGLV GELYVGGKGL AFGYWNRPEL
NQEKFIPHPF QQDSQARLYR TGDLVKFVPG RGIEFIGRKD NQVKIRGNRI ELGEIVAVLN
QHESVREAVV LVHEYGSDDK RLIAYIAGDG DVDEWKRYAS EQLPPYMVPS YFVKMDAFPL
TANGKVDRQA LPLPEIRTTK DEFVAPCTDT ENRIAEIWRE IVKVERLSIH DSFFDLGGHS
LLATLVISRL QDAFHLSIPL RVLFECPTIA SLDAKIMELG RDGKRVRTPA IARVSHRDKL
PLSHAQQRLW FLHQLEPEST AYNVPHMWRL TGKWDVHALE TGWNALLQRH EILRTVFANE
GGQPFQVIEP YVYRTLPVIN LRDRPAAEKE EQIQAYIEQE ADKRFDLQRG PLIQTKLIIV
EEDQFLLLCT MHHVITDGWS EDILLEEWLA LYEEAESGAR AELPELPIQY ADFAVWQREW
LTDEVMGQQL DYWKEELSGE LPVLQLPIDR PRPSIQTYAG SMHKIVLASE LLEKLKAFSR
QENTTLFMTL LAAYQGFLAR YTGQNDILVG SPIANRNVTE IEGLIGFFVN TLVYRANLQD
NPTFKQLLAQ VKEKALQAQE YQDVPFEKIV EMLQLERNPS YSPVFQTVFT WAEMGADVYR
TSSGQLEKMP VQINVAKFDL QLSMCESEDG LVMNIIYNTD LFDLSTIEKM TDRFAHWLHE
LVNAPDVPMA LLELLTEEER HKLLLEWNLT KATVFTQDSI PTIFEEQVEL HPDATALVYK
GTSLSYRELN SRANQLAHYL QACGVGVESR VGLYMDRSFE MIVSMVAILK AGGAYVPLDP
AYPEQRLFYM LQDASISIVL TQEGLISRLP DGLKIVCPDL DASEISKESD ANLGESTTSE
SLAYLMYTSG STGNPKGVLI PHRGVIRLTK QVSYVSLTPD ETMLQLASIS FDAATFEIWG
SLLNGAKLVI YPFPSLSLEE LGQVLRDEKI STLWLTAGIF HQMIDYRIKD LIGVRQLLAG
GDILSAKHAQ RALDMLPDTV VINGYGPTEN TTFTCYYPIK NKSAIQHSVP IGRPIDDTEI
YILSEMLKVV PDGLVGELYV GGKGLAFGYW NQPEMNEEKF IPHPFQQDPK ARLYRTGDLV
KYVPGRGIEF IGRKDHQVKI RGNRIELGEI VAVLSQHERV RDAVVLVHEY GADDKRLIAY
IAGDGDVDEW KRYASEQLPS FMVPSYFVKM DVFPLTANGK VDRQALPLPE MRTMKDEFVA
PRTDTESRIA SIWRDVLKTE TECLSIHDSF FDLGGHSLLA TQVISRLQEA FHLSIPLRIL
FECPTIASLD AKIKELGRDG KRVRTPAIAK ASHREKLPLS HAQQRLWFLH QLEPESTAYN
VPHMWRLTGE WNVQALETGW NALLQRHDIL RTVFSNEGGQ PFQVIEPHVY RTLPVIDLRD
RSAAEKEEQI HDTIMQEADR RFDLQRGPLI HAKLIVVEED QFLLLCTMHH VITDGWSENI
LLEEWLAFYE AAERRGRAKL AELPIQYADF AVWQREWLTD EVMSQQLDYW KAELSGELPV
LQLPIDRPRP SVQTYAGNMH KMVLTTELLE KLKALSRQEN TTLFMTLLAA YQGFLSRYTG
QTDILVGSPI ANRNVKEIEG LIGFFVNTLV YRANLQDNPT FKQLLAQVKE KALQAQEYQD
VPFEKIVEIL QLERNPSYSP VFQTVFTWAE MKADVYHSSS GQLEKMPVQI NVAKFDLQLS
MGESEDGLVM NMIYNTDLFD PSTIEKMTDH FANWLQELVN APDVPMALLE LLSEEERHQI
LVEWNDTAVA IPENTCLHDL FIEQAKKTPE LIAAEYGSEK ITYQELDRRS NQLAHYLMML
GVGPNTPVGI FMNRSIELVI SILGIVKAGG AFLPLDTEMP QARMTKLLEG SKTNICISEP
EFMNLFGQAT HVRWINSQAE KEKIASMPEG LPEQTVKPTD LVSIYYTSGS TGNPKGVENH
HFGWVNRMLW MQRQHGLEQG ESVLQKTTLT FDDAAVEFFW PLSVGGRISL LEPWLHRDPE
AIIQAAIHYQ VACIQFVPSM LNMFVDALTP EDAAKLHKLK NVISSGEALL PETVGKFYQM
LNAKLHNTWG ATEVSIDSTL YTCSPMDALE KDCVSVGKPI DNNRVYVLDQ NMKAVPIGVI
GDLYIGGLGL ARGYLHDHEK TKEVFMENPF VPGERIYRTG DKGYFLPSGN IKFVGRQDNQ
IKIRGMRVEL GEIESTLSRH PSVREAAVIS VKNDRSATEL AAYIVGDGDV NEWRTFLKEH
LPAYMIPTYF MKLASVPKTT SGKIDRNKLE LPVMKPSDFS IIQPRTIPEE LIHSIWCDIL
QVDQISIRDS FFDRGGHSLL ATQVISRMRT VFGMDIPLRT IFEFPTIEAI AARISEIKQG
SEANTRIHEV SRVENQRDVS LFEVSHGQRR QWFHAKFSDQ EAVGGVYLFE VAGPVESHSM
HRAMSLMFER HRIMRTTIIE NEGQLYQKVH DDLEVENAFV DLSALSVTEG EQRITADLQS
ALYKPFDFSR ESFFRMTLYR MTPSKHFLIL SAHHIGFDGW SLDVFINDLA DIYQQIESGV
QKEFSKPLDY MDYTLWQQTR LQNGELNRQR DYWLKQLQQN VDAPFIPRET HLLTHGNRIS
NVASLPIEPV TGQALLELTR MAGGTVYTSL LTAINIWLSL LTDQTILTVG STLSGRTQTD
LEGIIGPLIN PVAMRTDLSG NPSVLEMMNR TRETAYGAYE NQEYPYNLVI EDQLAATGDK
KNLYSIVFIG QHVSNNQPES DEITFTECPL RRFLDESIIK TYEGSHFVQD DQLDMMLFLS
TRHDQLTLTA HYNMEAFSEN AMNALLDQLK HVICQMIDNP MQRLSQINLV EEYDFNELFS
//