ID C0ZJV7_BREBN Unreviewed; 367 AA.
AC C0ZJV7;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN Name=citA {ECO:0000313|EMBL:BAH41408.1};
GN OrderedLocusNames=BBR47_04310 {ECO:0000313|EMBL:BAH41408.1};
OS Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599).
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=358681 {ECO:0000313|EMBL:BAH41408.1, ECO:0000313|Proteomes:UP000001877};
RN [1] {ECO:0000313|EMBL:BAH41408.1, ECO:0000313|Proteomes:UP000001877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47 / JCM 6285 / NBRC 100599
RC {ECO:0000313|Proteomes:UP000001877};
RA Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W.,
RA Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S.,
RA Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.,
RA Udaka S., Tanikawa S., Fujita N.;
RT "Brevibacillus brevis strain 47, complete genome.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; AP008955; BAH41408.1; -; Genomic_DNA.
DR RefSeq; WP_012684179.1; NC_012491.1.
DR AlphaFoldDB; C0ZJV7; -.
DR STRING; 358681.BBR47_04310; -.
DR KEGG; bbe:BBR47_04310; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_1_9; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000001877; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06109; BsCS-I_like; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:BAH41408.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001877};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 257
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 312
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 367 AA; 40032 MW; F0F2A08521DE46AC CRC64;
MTKQHPLAIG LDGIAVAETD LSLVDGINGL LVYRGHWARD LAIHHTFEEV AHLLWFGHLP
SEQELTDLKD KLKANRELPE HVKGILKLIP ADVDMMSVLR TGVSALGSSS HGFPPTIDEV
IALAAKMPTI VAYRFACLEG LEPLAPNPEL DHTANYLYML KGVKPNAAHV RALDAYLILT
QEHGMNASTF SGRVVSSTES DLISSITAAI GTLKGPLHGG APSEVTEMIE AIGTKENAEP
WLRNKLESGG RLMGFGHRVY KTIDPRATAL RVVASELSSN DPWFDLATHV EKVGLQLLEE
YKPGRKLNTN VEFFAAAVMR AVGLDDNLFT PTFAVSRVVG WSAHILEQAG NNRIIRPQSN
YIGTMPE
//
