ID C0ZX42_RHOE4 Unreviewed; 1130 AA.
AC C0ZX42;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=RER_22190 {ECO:0000313|EMBL:BAH32927.1};
OS Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus; Rhodococcus erythropolis group.
OX NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH32927.1, ECO:0000313|Proteomes:UP000002204};
RN [1] {ECO:0000313|Proteomes:UP000002204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT PR4 and Rhodococcus opacus B4.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAH32927.1, ECO:0000313|Proteomes:UP000002204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT "Sequence analysis of three plasmids harboured in Rhodococcus erythropolis
RT strain PR4.";
RL Environ. Microbiol. 8:334-346(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP008957; BAH32927.1; -; Genomic_DNA.
DR RefSeq; WP_020907130.1; NC_012490.1.
DR AlphaFoldDB; C0ZX42; -.
DR KEGG; rer:RER_22190; -.
DR PATRIC; fig|234621.6.peg.2722; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR HOGENOM; CLU_003630_1_1_11; -.
DR Proteomes; UP000002204; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 25..367
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 368..687
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 836..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 46..53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1130 AA; 120657 MW; 1B0BEC377A1716D6 CRC64;
MAAATQKARR PKIDPVDLAV ALGQHPPTPE QAAVIAAPLG PTLVVAGAGA GKTETMAARV
VWLVANGFVD PEAVLGLTFT RKAAQQLTSR IRKRLARLAG SDVLRALDPT GGVRSRILAG
EPEVSTYHAY AGRLLSEHGL LLPIEPSATL LSETELWQVA HRVVSGWDSD LDTDKNPGSI
TETVLALAGQ LAEHLVDPEQ LLEAHTELDK LIHTLPAGPK QRGGPSKELL NYLDVQHKRI
ELLPLVARLA ETLRREGALD FGSQMSLSAR VASEHPEVGQ TERERFRVVL LDEYQDTGHA
QRVLLSSLFG GGTDGRLALT AVGDPMQSIY GWRGASAANL PRFATDFPLA NGKPAPTLEL
LTSWRNPPEA LELANLSSAP LRRRGVAVST LRARPGAVAG DVRLALLGDV EQERQWVAEK
IAEEYEAARA EDRPTPTAAV LIRRNADAAP LAEALRSKGL PVEVVGLGGL LHTPEVADVI
AMLRVVADPL AGSAAVRLLT GARWQIGAKD LAALSQRSRE LAISAGYGTA GAVTDAEALT
SAVHDALPGE NAEQAGLVDS ISDPGPAERY SALGYTRINA IAAELASLRE RIGQPLTELV
AEVERVLGIG IEAGARTRVG VVGTAGREHL DAFADVVANY ATRPTANLTG MLAFFAAAEQ
IEKGLTPGEV EVAPDRVQIL TVHSAKGLEW EVVAIPHVSD GVFPSSTASG SWLGALAELP
PSLRGDRAVD ADSADGVPVL DLEELYNRKD LENAITAHKK ALSNRRLDED RRLFYVALTR
TERALFISAH HWAESGAEPK GPSEFLDELH QMVTADNDAG EEDSRGAIGV VEEWAPAPEP
DTENPLAATP RTAQWPPDPL GARRGAVEAG AASVLSALAS LPQDSEEAEE PEDDPENWAS
DVDVLLAERE ARANARAEVI LPAQLSVTQL VDLKADPDEL AARLRRPLPY PPNPLARRGT
AFHAWIERRF GATRLLDLDE LPGAADTGAG PETDLVKLQD AFLRSPWANR SPIEVEVPFE
TSIAGTVLRG RIDAVFADPD GGWTVIDWKT GAEPSTANED AVVMQLAAYR VAWAELMSAR
ARSAGRNEQF PADKVRAAFH YVRSGRTIAP ENLPDGEALA RLIRTAGAQD
//
