ID C1BAP1_RHOOB Unreviewed; 362 AA.
AC C1BAP1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN OrderedLocusNames=ROP_44970 {ECO:0000313|EMBL:BAH52744.1};
OS Rhodococcus opacus (strain B4).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=632772 {ECO:0000313|EMBL:BAH52744.1, ECO:0000313|Proteomes:UP000002212};
RN [1] {ECO:0000313|EMBL:BAH52744.1, ECO:0000313|Proteomes:UP000002212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4 {ECO:0000313|EMBL:BAH52744.1,
RC ECO:0000313|Proteomes:UP000002212};
RA Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT PR4 and Rhodococcus opacus B4.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; AP011115; BAH52744.1; -; Genomic_DNA.
DR RefSeq; WP_012691668.1; NC_012522.1.
DR AlphaFoldDB; C1BAP1; -.
DR STRING; 632772.ROP_44970; -.
DR KEGG; rop:ROP_44970; -.
DR PATRIC; fig|632772.20.peg.4705; -.
DR HOGENOM; CLU_009834_22_1_11; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000002212; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:BAH52744.1}.
FT DOMAIN 19..339
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 362 AA; 37874 MW; D9958A25867E3468 CRC64;
MTGAGTTEPE VLIDTSGGVG RIVLNRPRAI NALNHSMVRQ IAAALTEWAG DDQVRAVLIT
GAGDRGLCAG GDIVSIYHDA KTGGTGSREF WREEYILNAA IANYRKPYVA VMDGIVMGGG
VGVSAHGSVR IVTERSMIGM PETGIGFVPD VGGTYLLART PGELGTHIAL TTARLSAGDA
IACGFADHFI PSEQIAAFVQ KLSETSVEAA VAAFTAPAPA SDLLAQQGWI DAAYSADSVP
EIVSRLQRSG VPEAAKAAEQ ILSKSPTACA VTLASLRRAR AAGSLEDVLN DEFRVSVACL
NSHDLVEGIR AQVVDKDRNP HWSPATLDEV TDDDVAQFFT PLGDLELGLP HPTTTTTTGA
QQ
//
