ID C1BXU0_ESOLU Unreviewed; 281 AA.
AC C1BXU0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Interferon regulatory factor {ECO:0000256|PIRNR:PIRNR038196};
GN Name=IRF2 {ECO:0000313|EMBL:ACO13843.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|EMBL:ACO13843.1};
RN [1] {ECO:0000313|EMBL:ACO13843.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACO13843.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [2] {ECO:0000313|EMBL:ACO13843.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACO13843.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., Jantzen S., Cooper G., Davidson W.S., Koop B.F.;
RT "Esox lucius ESTs and full-length cDNAs.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSELUP00000019461.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [4] {ECO:0000313|Ensembl:ENSELUP00000019461.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038196}.
CC -!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PIRNR:PIRNR038196}.
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DR EMBL; BT079419; ACO13843.1; -; mRNA.
DR RefSeq; NP_001290945.1; NM_001304016.1.
DR Ensembl; ENSELUT00000041013.2; ENSELUP00000019461.1; ENSELUG00000018821.2.
DR GeneID; 105021338; -.
DR KEGG; els:105021338; -.
DR GeneTree; ENSGT00940000156288; -.
DR OMA; NRTDEHE; -.
DR OrthoDB; 3740806at2759; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000018821; Expressed in pharyngeal gill and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR017431; IRF1/IRF2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF50; INTERFERON REGULATORY FACTOR; 1.
DR Pfam; PF00605; IRF; 1.
DR PIRSF; PIRSF038196; IFN_RF1/2; 2.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038196};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR038196};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038196};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transcription {ECO:0000256|PIRNR:PIRNR038196};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR038196};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 11..119
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 123..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 32327 MW; 3696EC8A1DA2419D CRC64;
MRRVKEMHQG RLRLRPWLEE QIQSGKYPGV NWLDETAQVF QIPWKHAARH GWNIDKDATL
FRNWAMHTGR YKPGIDKPDP KTWKANFRCA LNSLPDVKEL QDKSIKKGSN AFRVYMMLPV
KSTKQQKGLP ESEGASQTSL SGTEAGSCAP LDRFAEVFLK YRGGQANHSP AIFHVKDNQT
PCNTIKEEWS PEQSYSHQSS FTSEVHESAD TTVNDNEQAE AVFKIVDHLK TMEHWNQSSD
NRNWRPAASS WLDCYCEDMD YLGYPMQTDC FTHSAAQRPF L
//
