ID C1D4W7_LARHH Unreviewed; 1052 AA.
AC C1D4W7;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN Name=acrD {ECO:0000313|EMBL:ACO75908.1};
GN OrderedLocusNames=LHK_02930 {ECO:0000313|EMBL:ACO75908.1};
OS Laribacter hongkongensis (strain HLHK9).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Aquaspirillaceae; Laribacter.
OX NCBI_TaxID=557598 {ECO:0000313|EMBL:ACO75908.1, ECO:0000313|Proteomes:UP000002010};
RN [1] {ECO:0000313|EMBL:ACO75908.1, ECO:0000313|Proteomes:UP000002010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLHK9 {ECO:0000313|EMBL:ACO75908.1,
RC ECO:0000313|Proteomes:UP000002010};
RX PubMed=19283063; DOI=10.1371/journal.pgen.1000416;
RA Woo P.C., Lau S.K., Tse H., Teng J.L., Curreem S.O., Tsang A.K., Fan R.Y.,
RA Wong G.K., Huang Y., Loman N.J., Snyder L.A., Cai J.J., Huang J.D., Mak W.,
RA Pallen M.J., Lok S., Yuen K.Y.;
RT "The complete genome and proteome of Laribacter hongkongensis reveal
RT potential mechanisms for adaptations to different temperatures and
RT habitats.";
RL PLoS Genet. 5:E1000416-E1000416(2009).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
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DR EMBL; CP001154; ACO75908.1; -; Genomic_DNA.
DR RefSeq; WP_012698371.1; NC_012559.1.
DR AlphaFoldDB; C1D4W7; -.
DR STRING; 557598.LHK_02930; -.
DR KEGG; lhk:LHK_02930; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_1_4; -.
DR OMA; ATFLIPM; -.
DR Proteomes; UP000002010; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002010};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 345..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 368..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 444..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 537..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 871..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 896..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 922..947
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 968..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 999..1025
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1052 AA; 112866 MW; 9D42276720C497F6 CRC64;
MFSAFFIRRP IFASVISILI TLAGLAAMRV LPIEQYPQIV PPQVTVTAVY PGASADVIAK
TVAAPLEQQI NGVDNMLYMQ SSSDSSGSMV LTVTFAIGTD PDQNTINVNN RVQAATAQLP
QEVRQQGVTV QKKSANILQI ATFSSPGGEY SELFISNYVL LNVLDELKRI PGVGDASIFG
SKNYSMRIWL RQDKLVQLGL TPTDVVSAIK DQNSQFAAGK VGAEPIQNPV DFTYTVTTQG
RLSDPAQFEN IIIRANPDGS AIYLKDVARV DLGAQDYNFA GTLNGKPTIP VGIYLAPGAN
QLQVAEDVTK ALAQMSQRFP TGLAYSIPYD TTSFVKISIE EVQKTLFEAM VLVFLVVYLF
LQNWRATLIP CLAVPVSIIG TFAGMYALGF SINTLTLFGM VLAIGIVVDD AIVVLENVER
IMSTEKLGPV DASIKAMQEV SGPVVAIVLV LCAVFVPVAF MGGLAGQMYK QFAITIAVSV
VLSGIVALTL TPALCALLLK EGHSHPNRFF VWFNNFFDRM TARYTAGVRF FLKRTGVGLL
VFAGLIAITV GLFRAVPSSL VPNEDQGYVL AAAFLPDAAS LSRTEEVMKQ FDQQMMKNPA
VANVVTFSGF DLLSGAYKTS AGISFVTLKP WSERKTAALS SDAVVGDVFR IGAGIKGGFL
MGLAPPPISG MSSTGGFEAY IQNRGSGGSA ALAEAVQKVV AAAQKRPELA GVSTTYSANV
PQLYVELDRE KAKSYGVPVS QVFDTLQSTF GALYVNDFNK FGRTYKVQIQ SESDYRSRPD
DLNKVYVRSQ SGQMIPLGSL IHVRWITGPE NQERFNVFDS AKVIGGPAPG YSSGEAIAAM
QEVTRDTLGD DFTIAWTGSA YQEIATGGTS AQIFIFALIV VFLILAAQYE RWKLPLAVLM
AVPFALFGAI LATWARDLSN DVYFQVALVT LIGLAAKNAI LIVEFAILKL DEGVDLIPAA
IEAAHLRFRP ILMTSLAFVL GCVPLVLSSG AGAASRHSLG TGIIGGMLGA TFIATFLIPL
FFVLIMRIGT RKKPKAPPPA AAAEHHSEEG QS
//