GenomeNet

Database: UniProt
Entry: C1D4W7_LARHH
LinkDB: C1D4W7_LARHH
Original site: C1D4W7_LARHH 
ID   C1D4W7_LARHH            Unreviewed;      1052 AA.
AC   C1D4W7;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN   Name=acrD {ECO:0000313|EMBL:ACO75908.1};
GN   OrderedLocusNames=LHK_02930 {ECO:0000313|EMBL:ACO75908.1};
OS   Laribacter hongkongensis (strain HLHK9).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC   Aquaspirillaceae; Laribacter.
OX   NCBI_TaxID=557598 {ECO:0000313|EMBL:ACO75908.1, ECO:0000313|Proteomes:UP000002010};
RN   [1] {ECO:0000313|EMBL:ACO75908.1, ECO:0000313|Proteomes:UP000002010}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLHK9 {ECO:0000313|EMBL:ACO75908.1,
RC   ECO:0000313|Proteomes:UP000002010};
RX   PubMed=19283063; DOI=10.1371/journal.pgen.1000416;
RA   Woo P.C., Lau S.K., Tse H., Teng J.L., Curreem S.O., Tsang A.K., Fan R.Y.,
RA   Wong G.K., Huang Y., Loman N.J., Snyder L.A., Cai J.J., Huang J.D., Mak W.,
RA   Pallen M.J., Lok S., Yuen K.Y.;
RT   "The complete genome and proteome of Laribacter hongkongensis reveal
RT   potential mechanisms for adaptations to different temperatures and
RT   habitats.";
RL   PLoS Genet. 5:E1000416-E1000416(2009).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC       ECO:0000256|RuleBase:RU364070}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC       ECO:0000256|RuleBase:RU364070}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001154; ACO75908.1; -; Genomic_DNA.
DR   RefSeq; WP_012698371.1; NC_012559.1.
DR   AlphaFoldDB; C1D4W7; -.
DR   STRING; 557598.LHK_02930; -.
DR   KEGG; lhk:LHK_02930; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_1_4; -.
DR   OMA; ATFLIPM; -.
DR   Proteomes; UP000002010; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; MdtF-like.
DR   NCBIfam; TIGR00915; 2A0602; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW   Cell membrane {ECO:0000256|RuleBase:RU364070};
KW   Membrane {ECO:0000256|RuleBase:RU364070};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002010};
KW   Transmembrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW   Transport {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM        345..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        368..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        444..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        472..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        537..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        871..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        896..916
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        922..947
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        968..987
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        999..1025
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
SQ   SEQUENCE   1052 AA;  112866 MW;  9D42276720C497F6 CRC64;
     MFSAFFIRRP IFASVISILI TLAGLAAMRV LPIEQYPQIV PPQVTVTAVY PGASADVIAK
     TVAAPLEQQI NGVDNMLYMQ SSSDSSGSMV LTVTFAIGTD PDQNTINVNN RVQAATAQLP
     QEVRQQGVTV QKKSANILQI ATFSSPGGEY SELFISNYVL LNVLDELKRI PGVGDASIFG
     SKNYSMRIWL RQDKLVQLGL TPTDVVSAIK DQNSQFAAGK VGAEPIQNPV DFTYTVTTQG
     RLSDPAQFEN IIIRANPDGS AIYLKDVARV DLGAQDYNFA GTLNGKPTIP VGIYLAPGAN
     QLQVAEDVTK ALAQMSQRFP TGLAYSIPYD TTSFVKISIE EVQKTLFEAM VLVFLVVYLF
     LQNWRATLIP CLAVPVSIIG TFAGMYALGF SINTLTLFGM VLAIGIVVDD AIVVLENVER
     IMSTEKLGPV DASIKAMQEV SGPVVAIVLV LCAVFVPVAF MGGLAGQMYK QFAITIAVSV
     VLSGIVALTL TPALCALLLK EGHSHPNRFF VWFNNFFDRM TARYTAGVRF FLKRTGVGLL
     VFAGLIAITV GLFRAVPSSL VPNEDQGYVL AAAFLPDAAS LSRTEEVMKQ FDQQMMKNPA
     VANVVTFSGF DLLSGAYKTS AGISFVTLKP WSERKTAALS SDAVVGDVFR IGAGIKGGFL
     MGLAPPPISG MSSTGGFEAY IQNRGSGGSA ALAEAVQKVV AAAQKRPELA GVSTTYSANV
     PQLYVELDRE KAKSYGVPVS QVFDTLQSTF GALYVNDFNK FGRTYKVQIQ SESDYRSRPD
     DLNKVYVRSQ SGQMIPLGSL IHVRWITGPE NQERFNVFDS AKVIGGPAPG YSSGEAIAAM
     QEVTRDTLGD DFTIAWTGSA YQEIATGGTS AQIFIFALIV VFLILAAQYE RWKLPLAVLM
     AVPFALFGAI LATWARDLSN DVYFQVALVT LIGLAAKNAI LIVEFAILKL DEGVDLIPAA
     IEAAHLRFRP ILMTSLAFVL GCVPLVLSSG AGAASRHSLG TGIIGGMLGA TFIATFLIPL
     FFVLIMRIGT RKKPKAPPPA AAAEHHSEEG QS
//
DBGET integrated database retrieval system