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Database: UniProt
Entry: C1DUB6_SULAA
LinkDB: C1DUB6_SULAA
Original site: C1DUB6_SULAA 
ID   C1DUB6_SULAA            Unreviewed;       271 AA.
AC   C1DUB6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C {ECO:0000256|ARBA:ARBA00017128};
DE            EC=5.4.99.24 {ECO:0000256|ARBA:ARBA00012785};
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase {ECO:0000256|ARBA:ARBA00030705};
DE   AltName: Full=rRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00031975};
DE   AltName: Full=rRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00033053};
GN   OrderedLocusNames=SULAZ_0719 {ECO:0000313|EMBL:ACN99569.1};
OS   Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC   Sulfurihydrogenibium.
OX   NCBI_TaxID=204536 {ECO:0000313|EMBL:ACN99569.1, ECO:0000313|Proteomes:UP000001369};
RN   [1] {ECO:0000313|EMBL:ACN99569.1, ECO:0000313|Proteomes:UP000001369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Az-Fu1 / DSM 15241 / OCM 825
RC   {ECO:0000313|Proteomes:UP000001369};
RX   PubMed=19136599; DOI=10.1128/JB.01645-08;
RA   Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA   Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA   Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT   "Complete and draft genome sequences of six members of the Aquificales.";
RL   J. Bacteriol. 191:1992-1993(2009).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA.
CC       {ECO:0000256|ARBA:ARBA00002876}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00000381};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876}.
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DR   EMBL; CP001229; ACN99569.1; -; Genomic_DNA.
DR   RefSeq; WP_012674881.1; NC_012438.1.
DR   AlphaFoldDB; C1DUB6; -.
DR   STRING; 204536.SULAZ_0719; -.
DR   KEGG; saf:SULAZ_0719; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_4_4_0; -.
DR   OMA; PKTHVYR; -.
DR   OrthoDB; 9807829at2; -.
DR   Proteomes; UP000001369; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR21600:SF81; 21S RRNA PSEUDOURIDINE(2819) SYNTHASE; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:ACN99569.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001369};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          11..73
FT                   /note="RNA-binding S4"
FT                   /evidence="ECO:0000259|SMART:SM00363"
SQ   SEQUENCE   271 AA;  31623 MW;  C068C96C70930338 CRC64;
     MIKKFYVKTT ANLKDFIAAS LNISKNQAKD IIDSRNVLVN NKRVWIASHT LKEGDVVEIL
     QPQQPATKEL KIIYEDEYIV AVNKPPTLLS DREKDSVEFI LREKSKNPKI KAIHRLDKET
     SGILLLAKDY KVFERFKELW EDKIVFKLYL AISHNEANFN HLTVNLPVDD KPAVSHIKLV
     KKGNGFSYFQ VRIETGRKHQ IRKHLSSIRH PIVGDKIYGV KKLEHNLLKR VNRQMLHSYK
     LSFFHPYKNK KIDLVAEIPT DFKNVLNYLN L
//
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