ID C1E204_MICCC Unreviewed; 1033 AA.
AC C1E204;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Anion exchanger family {ECO:0000313|EMBL:ACO61835.1};
GN Name=AE_1 {ECO:0000313|EMBL:ACO61835.1};
GN ORFNames=MICPUN_96291 {ECO:0000313|EMBL:ACO61835.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO61835.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO61835.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31.3) family.
CC {ECO:0000256|ARBA:ARBA00006262}.
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DR EMBL; CP001324; ACO61835.1; -; Genomic_DNA.
DR RefSeq; XP_002500577.1; XM_002500531.1.
DR AlphaFoldDB; C1E204; -.
DR GeneID; 8242186; -.
DR KEGG; mis:MICPUN_96291; -.
DR eggNOG; KOG1172; Eukaryota.
DR InParanoid; C1E204; -.
DR OrthoDB; 298198at2759; -.
DR Proteomes; UP000002009; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..504
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 509..775
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 86..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 110159 MW; FB092EFBF4EDAC45 CRC64;
MSESTSEVPG VGEPPRYVRF LQHLVAEGGY GLDESHALTG LKEWREAEVV GALLRNVKER
APDAVVGRIF TAVNQDGLVV LVGEAGEPEN GGDAHANGST EATSNGAHHV ASNGTEITSA
NGRAPRHRVL TDCHISVCTL DQPVNLGAPD GRNARAVFLV MVPEVDFTAP WAEGLDRYEC
LRTIKTAFQR FAARGTFLKT VYADERNLEA ATARQKLAEF LGERKSGDGD ADGDRDPELG
KSSGRMAAKA TSTRPTSPRM STGGSNLARQ KSIANMLTPG AKTTRLRPVD LVEALRASVA
AWADHEQRRL LLLADENERE TEAASMYQWT GRLCGGVIDD VTNRWAPLFV SDWIDGVSVK
TVSASLLMFF GCLAPCIAFG ALTDISTGGK MGTMEYLVAQ SVSGVVWSIF AGQPEIVLRT
TGPSTVFLIE LARACERDGY PFITAFAWTG IWSAMFMIAI ACLDACTLML RNCTRFTQEI
FGLFVSAIFI QSGGTALVSY FKSDEYDLAH ALFSLILALL TLQLGLWALQ VRTSPFLLPT
MRELTADFGV AAAIAVGTLT AYGSNVKGME MLKMTSSIEP ADGRGSWVVD LHAGPAHLKW
LAIVPALLLT ALMYVEMNIS SLLANKPENK LIKGPAHHQN FLVMALITLV FALFGLPPMT
GSLPHSPQFI RALSDVEEIT VGGETRTNVI WVRENRLAPL LVHVLMSLTI VMAPALRQIP
MAVLYGLFLY MGITGLATSQ LWTRIKMIAM DPRLLPPTHY VRKVPLTRVH AFTLVQMCCC
AALLGVRQSP AALFFPLFLG ALMPLRYTLT HEGVSLFTPE MLKMLDMIAE ASNAETAART
GRTDAEDHLT IRGDVADFDR SPNLSTSPSG DLKAPPGLGE NGVLATCLTN PSGVGVLSGT
LVCATDLGTR RILRPKILPL ALTSAQAAGT PNTSAVATRT VVGVTCGCSA STLPASFMAN
ASTSVNIRIA VASAAVDTAV TPSAKAFAPS PARGAAFSKT ALADEVAVVI SGSVASWSAV
ASSMTYPGAM VLA
//
