GenomeNet

Database: UniProt
Entry: C1E598_MICCC
LinkDB: C1E598_MICCC
Original site: C1E598_MICCC 
ID   C1E598_MICCC            Unreviewed;       514 AA.
AC   C1E598;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=MICPUN_81102 {ECO:0000313|EMBL:ACO62855.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62855.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62855.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001325; ACO62855.1; -; Genomic_DNA.
DR   RefSeq; XP_002501597.1; XM_002501551.1.
DR   ProteinModelPortal; C1E598; -.
DR   GeneID; 8242505; -.
DR   KEGG; mis:MICPUN_81102; -.
DR   HOGENOM; HOG000042486; -.
DR   InParanoid; C1E598; -.
DR   KO; K00029; -.
DR   OMA; KVLDYAY; -.
DR   Proteomes; UP000002009; Chromosome 4.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT   DOMAIN       28    212       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      222    481       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE     51     51       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    126    126       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       197    197       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       198    198       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       221    221       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   514 AA;  56330 MW;  37347F9536F66BCE CRC64;
     MSATLSALNG FRAASRAIDK YVFLRQLQHE DAGVFYRLLV NNAMEIMPYV YTPTVGEACQ
     TYHTLPIAQQ GVYITADDKG RVGEALRSRA PPSLANDLKV AVVTDGERIL GLGDLGAGGM
     GIAEGKILLY SVCAGIRPNQ CLPVCIDVGT DNKSLLEDPM YKGLRRERLR GREYDEVVEE
     FMSEMRSWQP RCLVQFEDFG NTNAFRILER YRHRQPCFND DIQGTACIAL AGVLSGLRTT
     GADLTEQRIL FYGAGEAGVG IGELIAMALE KRGMSHHDAI NRCYFMDSKG LVCKQRLDAP
     QTPKHALQPH KVAFAHDVPY EPDLLSAIDA IKPTVLIGVS TIHGAFDERV VRKMAAINPR
     PVIMPLSNPT SKAECTFEQA VTWTEGRVVF ASGSPFPAMT YRGKTLHPAQ ANNAYVFPAL
     GHAAVLAGAR EVSDDAFLAA AEALSAMTTE AELAAGKLFP DFDSIREVSH DLTARVCELM
     ERDGQGVKPA GVTDWKKYVD SQFWEPEPET PSKL
//
DBGET integrated database retrieval system