ID C1EA29_MICCC Unreviewed; 471 AA.
AC C1EA29;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN Name=FUM-2 {ECO:0000313|EMBL:ACO64785.1};
GN ORFNames=MICPUN_96474 {ECO:0000313|EMBL:ACO64785.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO64785.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO64785.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; CP001328; ACO64785.1; -; Genomic_DNA.
DR RefSeq; XP_002503527.1; XM_002503481.1.
DR AlphaFoldDB; C1EA29; -.
DR STRING; 296587.C1EA29; -.
DR GeneID; 8245167; -.
DR KEGG; mis:MICPUN_96474; -.
DR eggNOG; KOG1317; Eukaryota.
DR InParanoid; C1EA29; -.
DR OMA; AKWRAQT; -.
DR OrthoDB; 1341425at2759; -.
DR Proteomes; UP000002009; Chromosome 7.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT DOMAIN 4..332
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 399..451
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 471 AA; 50473 MW; ECF29EB1057528F9 CRC64;
MGVVRVPADK YWGAQTQRSL QNFKIGGEKM PMEMLRALAI VKHAAATVNE RLGKLDSRRA
EAIRVAAREV IEGKLDDNFP LVVWQTGSGT QTNMNVNEVI SNRAIEMLGG VVGSKDPVHP
NDHVNMSQSS NDTFPTAMSV ATAYEVQEGL VPALRLLRDE LDKKSREWES IVKIGRTHLM
DAVPITLGQE FGGYAQQLRN SLLRAKAAMV HLTELAIGGT AVGTGLNSHP RYAELMAQEI
SVLTGLPFVS APNKFESLAA HDAQAALSGM LKTMALSLLK ISNDIRMLGS GPRAGLGELN
LPENEPGSSI MPGKVNPTQC EAMMMVCAQV VGNDMGVTLG GAAGSHFELN VAKPLIAFNN
LQSIKLLSQA SVSFAENCVR GIAPNLERID ELMRSSLMLV TALNPHIGYD KAAKIAKKAH
KERTTLKEAG VSLGILTAAQ FDEWVRPELM TSPEGEGAGH AGLALASSSR L
//