ID C1EGN9_MICCC Unreviewed; 963 AA.
AC C1EGN9;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=MICPUN_88167 {ECO:0000313|EMBL:ACO67159.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO67159.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO67159.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP001332; ACO67159.1; -; Genomic_DNA.
DR RefSeq; XP_002505901.1; XM_002505855.1.
DR AlphaFoldDB; C1EGN9; -.
DR STRING; 296587.C1EGN9; -.
DR GeneID; 8248832; -.
DR KEGG; mis:MICPUN_88167; -.
DR eggNOG; KOG0355; Eukaryota.
DR InParanoid; C1EGN9; -.
DR OMA; THHWLLF; -.
DR OrthoDB; 1043at2759; -.
DR Proteomes; UP000002009; Chromosome 14.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 112..575
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 812..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 103514 MW; D745665396ACC7C7 CRC64;
MSNVASVRRA ARSAASSSAL RSHLGSLRGF WGSSSSTAAL AAPDAAWGTR WTRRSAVVAA
LGDTRGTFDR TRDPRRRLLS SDARGGNVAT RVVTGGGGGG DTGVEDERIV DLELHLEASQ
SYLSYAMSVI VGRALPDVRD GLKPVHRRIL YAMHELGLDS KKPFKKCARV VGEVLGKFHP
HGDQSVYDAL VRMAQDFSMS SALVDGHGNF GSLDADPPAA MRYTECRLKP AAEAMLLADI
GLDAVDFTET FDGSQTEPAV LPARLPNLLI NGSTGIAVGM ATSIPPHNLR EVANALVRFA
SDPERCTLED LLEVMPAPDF PTGGIIVQQR GGFKEMYRTG KGGVNLRGAA TVEKVSGGGR
NGQARDAVVI TSIPYQTNKA SLCEQIADLV NSRTIEGVSD VRDESDRDGM RVVVEIRRGA
DANFVLDQLY ARTKLQTRVS VNLVGLVGRE PKVLSLMEIM REFLAFRCDA VERRARHELQ
KASGRLHVVE GYLAVQAAPD AVVAAIRAAK DGPTAQAALQ EKPFWLSEKQ AEAVLAMPLR
RLTGLEHDKL KTEEAELTAR VEDLTGLLGD RSRVIATVAR EAKELRDTFG VDRRTDIDTD
AQIHAKKMNV TLDMLNSPSL VIMTNRGYIK RIDPAVFSKQ NRATRGRNMG KMRGGDEVTK
VTHCNGLDTV LFFTDRGRVH AVRAFNIPQA STSALGTPFT RVLKLAEGES ITAMLPVDTT
EEPGEEGETS LCFVTARGLI KRTCASEFVG IRNNGKKALV LRKGDRLKHV DIVKKGDGII
IGGIDGSVIH FDADSVRAQG RAAAGVKAMA FKPDGLDDTS EDDDTSEALP ANASAGDVED
DSEEDGEDED AKGPMLFFVS SDGRGKRISV AQFAQQSRAG RGKKGMGLMK GSKLAALCLT
GLDSDEHEHV IIGSQGGVMN RYDVASIRPQ SGRAAKGVNV MKLSDGDTVR DITLLPAELG
DDE
//
