ID C1EJC8_MICCC Unreviewed; 4514 AA.
AC C1EJC8;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Dynein beta chain, flagellar outer arm {ECO:0000313|EMBL:ACO68015.1};
GN Name=ODA-DHCB {ECO:0000313|EMBL:ACO68015.1};
GN ORFNames=MICPUN_105018 {ECO:0000313|EMBL:ACO68015.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO68015.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO68015.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
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DR EMBL; CP001334; ACO68015.1; -; Genomic_DNA.
DR RefSeq; XP_002506757.1; XM_002506711.1.
DR STRING; 296587.C1EJC8; -.
DR GeneID; 8249838; -.
DR KEGG; mis:MICPUN_105018; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; C1EJC8; -.
DR OMA; ICEHMAY; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000002009; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF36; DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846, ECO:0000313|EMBL:ACO68015.1};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 198..769
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1290..1696
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1832..2160
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2317..2438
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2655..2747
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2798..3057
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3071..3412
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3438..3657
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3916..4035
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4067..4212
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4219..4511
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 172..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 784..837
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1747..1774
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3055..3106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3292..3347
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4514 AA; 511821 MW; 84C06B70F5A213C0 CRC64;
MAEEEDEENK VPKVDPIVFL RDWFKTRVLS SLKCKEDLVN GLIDKEPSAT AVDSFWKESE
VQRLIVYFKD AELLATVNPP DRFKKKTLCF LKLAPVKLDP ENVDQKVIFG DFGDVPLEHL
STVAQEVFLP VLTNPRNQHG WPEVITREVI ENMHKFIASV YVTIGQTKGK TLLPMPPSDA
STAVSGADTA GTSTTDQIHT LESAIVTWTR QIKNVLRTDP EHALMRDDGE HPGPLTELEF
WEDKAANLNA IHEQLSGAKI RKVVKVLELA KSSYFPAFQK LCKEVAHARV EANDNLLFLK
PLDKYFTKLQ NNQDEFEGLV ELFKPIMHLV MLVWKHSHHY NTPGRIVVLM RQICNDLIMQ
SQKFLPGGEI FGLEPPEAVE KLKLLLRVLG SFKSFYFEYK GKTTRETPQN PWKFQNSALF
ARLDAFLERC HDILDLTQTV LQFNKLERVE VGGTKGKALS ANVRQIHADF VEALEKLHQV
EYDVMDVESK KFDDDFYEFR SVIKELERRL GSVIIQGFED CVTVGTAFKL FDSFEGLLER
EIIMADLEKK QMELVRFFGA DLKEVESIFN SQRDKPVVGK NLPPCSGAVK WVRALHERVK
DPMEKLTSLN KLVMETDESR EVTELYERIA AQFEEYETQV LKNWAKEVDA TGEEKLKLNL
LAYDEKAEIP GILRVNFDPK LVKLLRETKY FMLLDSSVPA SARKIYERNE TLRQQTGNLD
LIVGTFNNIL RTLLPVERPL VASKIENIEE MLQKAITTLN WNSHKINDYL AEVMTHVKEL
DTVLNYLKNS VEKTQNVLRQ WEENLMIDRK DGKTYAVDEF KEMQEKLQAE RDEKIADGGV
EITKFLQMSN KKVNVPRASK AWREYVEYVN EIVMEGYANA ILASLKYLNE QVNSAILAET
EQAPLLEVSL ELAVPDVQWS PEIGQSGDPE RPGVRDLING WVRAFQNTGT LVRRLDIGEG
NYMKELEEDF YILDGVSELQ AVILANEAEC VAFKEGYDKY EYLWRNDLNA TLAEFIETNG
ADGDDPELDV FDAEIAKYKA VQEEIAHLTT SAVIGWIRID AKPMKQALAT WVTKWVFLFT
HYLSNKVVNS MSELYEFMAR GDVVLAKDPT EANKELDDAG RNELLYEMMG YMRDLRKRQD
KTDGMFEPLV ATVALLKTYG ISISEDVLKQ LEEAPLAWSA LKKKSLNVKE KLSMMQQLEA
RKIREASDAF AKKVEDFREL FQKLAPFSVK GKITTDAIEP AYAALDHFHH GKKDSKYVFG
SITDVVVESA ELNEKQDLFE LIVTDYVALR KSSEDLTNLK LLWDMISSVI YTFTSWNTTL
WDKIDVDYLV EETKKLQKET KQLPKGCAQY DVFRTLGDQV KALLTSLPLV AELRHPAMRE
RHWKLLQQVT GKKFTMDEKF SLGDLLALEL HTCADSVSEI VERAQKELVI EKQLVKIEKD
WAGLHLDFVP FTPDSDVVNI VVDDLIVEAL ENDNLLLQNL GSNKYVQGTK FQEIVDEWQK
KLGTVDSVLS VWADVAKKWS MLESVFIGSQ DIRVQLPEDS KRFDGVNTEF TNMMRDAPDV
TNVVEACNVD DRLENLERML SLLEMCEKAL QDYLETKRIA FPRFYFVAPA DLLDILSKGT
NPQMILRHLS KCFDNIHNLS FEPDEMGNPS KNAISMWSGE KENVAFAGKC MCEGPVEQWL
NVVVETMRAA LFHEFKLSVP KYDQMPRTKW MFEQSAQNTI TVSRLIFTQE VNEAFDRLED
GDDNAMKDLL QKQLDQLKGI IEAVNGKLEK LDRKKVLTLC TIDVHARDTC QKLIDEKVDV
ADAFQWSSQL RYGTNEKTGK LQINVCDAEI PYMYEYIGSP GCLVITPLTD RCVITLTQAQ
RLVLGGAPAG PAGTGKTETV KDLGRALGIQ VYVFNCSDQM DYKAMGSTYK GLAQTGAWGC
FDEFNRIPVA VLSVCSTQYK TVLDAIRAKK SQFMFEDVEI SLRPSTMAFI TMNPGYPGRA
ELPESLKALF RPVSMCVPDL GMICENMLMG EGFQMSKLLA RKFVILYRLC QDLLSAAPHY
DWKLRAIKTT LYVAGGLKRD QPHLTEDKVL LQALRDFNLG KLTSDDHGIF MGLLNDLFPK
MLADVPRQRD ESFEAQITKS AIELGYQPEE MFVLKITQLR EIFTVRWSVF LLGPAGCGKT
AVWKTLLHAQ NEYGEKGKAV PVNPKAVSRN ELYGFLHPAT REWKEGLMSV TFRDMSNNTS
YVHQWIVLDG DIDAEWIESM NTVMDDNKML TLASNERIPL TGTMRLLLEI NHMFHCSPAT
VSRGGVIYLN QDDIGWKPMV DSWIEAREAT EYRPILIELF DRYMPRSLEH CRRAFRTIVP
LVPMNIAGTV CKILDGMIPK EATRGAPAPD RKLVEMQFVF AATWALGGAM LVDKTVDYRA
QFSKWWVAEW KNVLYPEEGL VFDYYVDPVS MQMRPWEEKV EGFGYNPSEA FANIFVPSVE
STRLSYFLNS FIKNKHYCMF VGNAGTGKTA LMRETLRALD SENWCFSTIN MNNFMDAPAL
QVIMEQPLEK KSGVRFGPPG AKRMVYFFDD LNMPYVDKYD TQTPIELARQ NIDYKGWYDK
QKIVLKEVLN CQYMACMNPT AGSFNITPRM QRHFATFAVQ MPSKAVIATM FAQIIDGHLK
NFDPDISKFA QKVADASIEL HNLVANTFLP SAVKFHYQWN LRELSNITQG ICRTLPEFYT
NPADLVRLWI HECERVFSDR MTLISDIEKF DNMRVTVTKK YFEDQDMEAI EARPISYNAF
IQHDSQDNGA YCPVDSYEKL NKTLVDKLNE HNESNAVMDL VLFNQAMDHV TRITRILDLP
RGNAMLVGVG GSGKQSLARL ATFICGFEVF QISVTSSYGM ADFKVDLFEL YKKAGAKGQP
VTFLMTDGQI VQERFLVYIN DLLSSGYIPD LMSNEEKEEM CNAVRKEVKE AGILDTPENL
WDFFLDKVRK YLHVCLCFSP VGDKFRIRAR NFPALINCTV IDWFQPWPHE ALVSVAGRFL
SEIPEIEPEL LENLQYHCAH AHMSVNDASN AYLDEDRRYY YTTPKSYLEL ISLYKDMLAN
RRQALSEAKA RLENGVDKIA FASAQVNELQ VNLKQEQIIV EEKKKATDQL IVSIGKEKAV
VDAAVEAGAA DEAECAAIAE EVSAVQAECA EDLAKAEPII QEAEAALNSL DKKSLGELKA
YSNVDKMISA VTAAVMILFA KGKIPKDVSW NAAKKFMGSV DGFLTNLVNF DKDNVKEECV
AEVESKYLTM PKFTVADIEK KSGAAAGLCS WVINICKYFR IYQEVAPKRA ALADANAKLD
AANEKLSGIR ARVKELQDKV AALEDNLMKA TEDKNNAIAA AEKTQRKADL ADRLVNGLAG
ENKRWGESIQ EMSVSYSKLV GDVLVASSFV SYAGAFNAKF RKSLVHNKWL PDLVERDIPM
TAGVVPLDVL TTDALKAQWG IEGLPTDPLS IENGAIMTAA KRWALMIDPQ LQGIKWIKEK
WGDKLKIIQL SKPNYIADVE HCIENGIPLM IENLQDDIDA VLDPVVARQT MKRGRSTVMK
LGDKEVDYDP NFKLYLQTKL SNPHYKPEIA AQTTLVNFCV TEKGLEDQLL ALVVEKERFD
LQEQSSNLVR QLGEYTVQLT ELEDNLLVRL ANAQGDILED IALIENLEET KRTATEIAEK
VEVASETQIS INQTREVYRP VAARGALFYF LIDVLNVLDR VYQYSMANYI YILKKGMDIC
PGGSDGEQWV PEEKKLGKEL PVEQRVPALT ESVTSAVFGY ISAGLFERHK LIMATQLTMG
VLRQQGKLDA ELFDWLLRAP RSEGMDNPLP EWLGEANWEM VNSIREFEQY AALGDDLVGS
AKRWREWMEL ERPEEEPMPG DWKKMEQFEQ LLLFRALRPD RMSNALGTFV KNTLGERYVT
SDPFDLASSF EDSAPGTPMF IFLSPGVDVA AAVEHLGRKL GYTADNGKYA SVSLGQGQEP
IAMNNLKNFH KSGGWVLLQN IHLTIDWTNG PLEKTVDKLA EGAHENFRLF LSAEPPPSLE
RGLAISLLQN SVKLTNEPPE GMKQNLARAY NNFTEEMFEA CAKQGEFKSI IFALCYFHAA
ILERKKFGVG NLPDAASGIG WNMNYPFNTG DLLCCGQCVN NYLENNSKVP WDDLKYIIGE
IMYGGHVVED WDRRTVAMYL ESYFKEELLE GIEYFPGFPS PPSGLNHKQT MAYIEENFPT
ETPLAFGLHP NAEIGFKLRE AESLCAAILS LQPRDGGGEE GSSVEDKAKT VLDDLVDRLP
EQFDMEDIRG RTEEITPYIM VAIQEAERMN VLLAEMKRSL AELDLGLKGD LTMSDPMEKL
MMALADGAVY AGWAKLAYPS LRSLGSWVNN LERRVEQLAQ WCSDLQLPKA VWLSGLFNPQ
SFLTAVMQTT ARKNDWPLDK TVVLTEVTKK QPEQIEGPAR EGAYIHGLTL EGCRWDEKAG
CLDESRPKEM FCPMPVIIIK AVTVDKAEMK DAYQCPVYKT ERRFREEVFT AQLKSKHGQI
KWTLSGVALF LDIC
//
