ID C1F8W1_ACIC5 Unreviewed; 310 AA.
AC C1F8W1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:ACO33744.1};
DE EC=3.5.4.4 {ECO:0000313|EMBL:ACO33744.1};
GN Name=add {ECO:0000313|EMBL:ACO33744.1};
GN OrderedLocusNames=ACP_2020 {ECO:0000313|EMBL:ACO33744.1};
OS Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS 7670 / NBRC 15755 / NCIMB 13165 / 161).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Acidobacterium.
OX NCBI_TaxID=240015 {ECO:0000313|EMBL:ACO33744.1, ECO:0000313|Proteomes:UP000002207};
RN [1] {ECO:0000313|EMBL:ACO33744.1, ECO:0000313|Proteomes:UP000002207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 /
RC NCIMB 13165 / 161 {ECO:0000313|Proteomes:UP000002207};
RX PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR EMBL; CP001472; ACO33744.1; -; Genomic_DNA.
DR AlphaFoldDB; C1F8W1; -.
DR STRING; 240015.ACP_2020; -.
DR KEGG; aca:ACP_2020; -.
DR eggNOG; COG1816; Bacteria.
DR HOGENOM; CLU_039228_7_0_0; -.
DR InParanoid; C1F8W1; -.
DR Proteomes; UP000002207; Chromosome.
DR GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01430; aden_deam; 1.
DR PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ACO33744.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002207}.
FT DOMAIN 20..305
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 310 AA; 35267 MW; DFFAFF1C282296D5 CRC64;
MELSRQAGRQ PLTLDAARAL YRYTDFTGFL MAFKAISEQL QTPEDYEHIT WRMLEDLARQ
GVVHAEVYVS VGVVYYWRRI EFEPLFEGME RARIRAEREL GITLYWIFDA VRHFGPEEAA
RVFRKAAELQ PAHPSISGIG IGGDERRTGP EPFRELYAEA RDAGLRLTAH AGETTGPESI
WGALNIGAER IGHGLSAIDD PELMEVLATR QVPVEICITS NVRTGCCPLL HDHPVRRYFD
SGLMITLNSD DPALFGSDLE GEYRIAHENF EFTPEHLREL ASNSIEASFL PPERKLEWLQ
RIEAWEHITS
//
