ID C1FGS1_MICCC Unreviewed; 465 AA.
AC C1FGS1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=NhaD Na+:H+ antiporter family {ECO:0000313|EMBL:ACO69311.1};
GN ORFNames=MICPUN_107049 {ECO:0000313|EMBL:ACO69311.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO69311.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO69311.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC family. {ECO:0000256|ARBA:ARBA00025753}.
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DR EMBL; CP001575; ACO69311.1; -; Genomic_DNA.
DR RefSeq; XP_002508053.1; XM_002508007.1.
DR AlphaFoldDB; C1FGS1; -.
DR GeneID; 8245965; -.
DR KEGG; mis:MICPUN_107049; -.
DR eggNOG; ENOG502QQAH; Eukaryota.
DR InParanoid; C1FGS1; -.
DR OMA; YQWLLVT; -.
DR OrthoDB; 298117at2759; -.
DR Proteomes; UP000002009; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR045016; NhaD-like.
DR NCBIfam; NF038006; NhaD_1; 1.
DR PANTHER; PTHR43269; SODIUM/PROTON ANTIPORTER 1-RELATED; 1.
DR PANTHER; PTHR43269:SF2; SODIUM_PROTON ANTIPORTER 1-RELATED; 1.
DR Pfam; PF03600; CitMHS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 28..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..411
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
SQ SEQUENCE 465 AA; 50394 MW; F32E8E445060248F CRC64;
MKEAADPMVY TEDGKSGKRP MHNMTGTWQG ALSLLVFIAG YTAAIMEESV GHGFKKSIPI
TLAAGIIWVL VALGYRDKGH SLYFVTTAAR HNLTEFVEVF LFLLCAMTFI NTMHRLNVFN
KLRWFLVESG FSYRSCFWIT GLIAFWLSPI ADNLTTAVLM GAVISNLGHG YDEYVAMCCV
NIVVAANAGG AFSPFGDLTT LMVWQKGKVR LEEFPGLLAP AVVNWLVPAF LMNRRIKDAV
PPRVEGEVAV QLLPGAVEVI LLFVATVFMT ACFHSYAHLP PVLGMMTGLG MLKVYGWKVP
GKGGDASPDG DGDVPTRRDH ALDIFKRLEQ TEWDTLIFFY GVIMCVGGLG VMGYLSALST
FMYGNFGPNI ANVALGALSA VIDNIPMTYA VLQTDPLMTT TQWLLLTLTA GVGGSLLAVG
SAAGVGLMGV NSRCYTFRSH LRWTPAVALG YLASVVVHLA VNGFE
//
