ID C1FZ50_PARBD Unreviewed; 2893 AA.
AC C1FZ50;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEH44787.2};
GN ORFNames=PADG_01076 {ECO:0000313|EMBL:EEH44787.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH44787.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH44787.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH44787.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN275957; EEH44787.2; -; Genomic_DNA.
DR RefSeq; XP_010756108.1; XM_010757806.1.
DR STRING; 502780.C1FZ50; -.
DR GeneID; 22580806; -.
DR KEGG; pbn:PADG_01076; -.
DR VEuPathDB; FungiDB:PADG_01076; -.
DR eggNOG; KOG1910; Eukaryota.
DR HOGENOM; CLU_000592_0_0_1; -.
DR InParanoid; C1FZ50; -.
DR OMA; FKKVIMK; -.
DR OrthoDB; 607689at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019443; BLTP2/FMP27/Hobbit_C.
DR InterPro; IPR019441; FMP27/BLTP2/Hobbit_GFWDK_RBG.
DR InterPro; IPR019439; FMP27/BLTP2_N.
DR InterPro; IPR019409; FMP27_sixth_RBG.
DR InterPro; IPR019415; FMP27_SW_RBG.
DR InterPro; IPR019449; FMP27_WPPW_RBG.
DR InterPro; IPR045167; Hobbit.
DR PANTHER; PTHR15678; ANTIGEN MLAA-22-RELATED; 1.
DR PANTHER; PTHR15678:SF6; PROTEIN KIAA0100; 1.
DR Pfam; PF10293; DUF2405; 1.
DR Pfam; PF10351; FMP27-BLTP2_C; 1.
DR Pfam; PF10344; FMP27-BLTP2_N; 1.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR Pfam; PF10305; Fmp27_SW; 1.
DR Pfam; PF10359; Fmp27_WPPW; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
DR SMART; SM01215; Fmp27_SW; 1.
DR SMART; SM01216; Fmp27_WPPW; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1124..1226
FT /note="FMP27 SW motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01215"
FT DOMAIN 1244..1403
FT /note="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01214"
FT DOMAIN 1648..2173
FT /note="FMP27 WPPW motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01216"
FT REGION 692..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1888..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1995..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2779..2893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1900..1921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2531..2551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2599..2640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2779..2844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2848..2870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2893 AA; 326674 MW; B4288A1EF62399FD CRC64;
MAVWSPTTVF VALFLIYLTS FIFLAIIRIA TGISIQRIGY FSLRRIGYSP KEGVKISIRQ
LGLSIHRPSF AQPTYISVKL RELAVTIDLP ALNSHQRDAK KRTLAEESDD VSEKDDVLGA
GFQPGPYHKT RSKAWKMLTM SKEWIKILHR QIQWLAIVDV VATDTILKVV DAGEIQIGGL
TMAVDTRKKM MARGRLFRHK KDPHGDRRPA EWIFNVRNIM LAVDDCEAVE ILDNLGLTIH
GILHKDLEGL RDVSIAVKAG RLHVPYDDLV KLGTRMKESL PIQKNAAGEL TGDGISSEDT
VQELSQPGSR QEAIFQTVTD SREFLSSLLR GIQEIQVALS FFRLSQVVQT VQPQRPLYLN
VVTHEVGIDL HRMDPNRPAH RMYFQRDDIA HQALLAAISL SVSLDDNIGQ TDKILYVPMA
TTTIKTTFPS KTVSYSEHRG VAERNTNVLF ANLVVTSPSI DLEPKHLSQI RDILQRTKPR
SRSKVRNNHV LISHILPKAS IKLSIHEPVL RFVLPSPETG KDNNYNLLIS SISSISLDIE
SSHSAEDGIH YSLSSIYRVA SHQLYYQTFS GNKHRLLATQ TMEVNIHLNA TPEVCVVASG
TLNTFSIHLV SGEVSRGVNQ VVDQFHSHFQ PKKLSSLEAN HPSFFRRLPP WLLQFQFEAS
GFSVEVAGID NTIGTTTRGM VLQLQGWTAD YESQKAEPNR RSVKRRTPSH SASSDDHSFR
FASSSPSRKS QHGPADGRRL VFHVRGLEGF VIESADFMEP ESFVSVPRFE VALSTSSDLQ
GPIFHINSTV KSIYLDCSLY QSYAVGIAVS VLRDALLRPT TKPTTTTSPT KIVPVKFPIN
PSSAEIITVD VKASLIQVKC LMPADPSMML QIYGFAAGRH RWSAPFMRSQ LIRLHAEAPK
LKGAWARVVS VNNIRVGLRE SQRRPDGTVI EEKSIDISTE FIRLAVPHQM IMYRIFDNFI
NTAKSVQQLN HRFKTRTNEY VLEKHPEGPK HVPRISLRSK ALLFELEDDA FEWKIGSIYR
LGLLEQKQRL AREEAFRMKS RRLEELQQRQ ASSRYRTQSI NGIPTRSTAR SRKSNEDVRR
SKSADGRRPH TRSQPRGRRP NRAVRYNPEG VPAISDSFKV SSNEAWFKLQ EHNARSWKMS
IDNNMRFQNT AIKEIRLMFS GADEPPEDMQ DDENILSVPD RPGLLSALIS DVHLVIDKPS
FPIDEYPIFL HRIGKGMPLD MKYSLLIPMN VQLDMGEARG NLRDYPLDLI HIPALRAGQS
SRLPSWSLRT DFVIAEEFRD YESSRHVIVN VVPPNEVADG VTNPGFSIDV RRTVSPVKTY
SDAIIEINTN LPTSISWGMS YQPVIQDMMK IIEGFSKPEI DPSERVGFWD KIRLSFHSRI
NVVWKGDGDV HLRLKGSRDP YVVTGFGAGF VMCWSKDVQW EIHTRDDPRE FMAVTSGEYV
LAIPDYSHQA RNSYEVTLDY GSTSSRCISK DCALFKKVIM KLSGNVRWLS GLVFERNVDG
SERSFVFKPH YDVVLKNPRY ISPDELKDYD AFRGFRSNHI HLSLAIVAPV SRVWSVSNRE
PSTSYNTVHL TPRFFTHFFS WWSLFSGVMS LPVRQGSLWP ELTKISKKFG RHLATVKYNL
FLSPLFVAHI YKHKDAHDYG EDMASATGIK VRLDSFMLDL HQRREQVNVM VKGRSKQTKA
SEMRINRAQL DFISADFRAV SVSIAGTNPE EGNVASDILS AYQQPVPPAD LSRFTIPDKD
LNWVDMDDFV EVDWMLPSES NPRTRILPLA YSPRFSYFRQ TDHEERSVDE TGYSPFGDEP
SHYCVMSQDN DPRRVQMELI KERLDMIDAQ IAAHNRMIGE QELRIVRDSQ AADGMKSQFE
LFVRQGESLQ RRRKFLVSGL RRLEKHLAGD AEPNGLGSES IHSRPASESE PFASSENGSN
DADIDGLYAS PDDEFISDFD NRFIIHNIQL KWNNSLRNII LRYIHQVNQR RGFVYYMSRR
AVKFILDIVE EQGKSKLRPR EAGKQPPTPT PSQEHEGHDG DDDISIEDRI EQLLGNANQF
FKADDSTPKA ARRRSSVVDG AEKIAPDFTP QNSYHLRLIA PQIQLQSEKN KKAVALITAK
GMQLKVVSIM DKHRVSDDVS GLVQRRFTLD MDSAQFFVTT QESLFKHLHL YSGNRYGNAP
GSAWPPWVSL EGMVDFDLEP SGFSRIIQKT SASLRYDKYN TLRLKYNEKI ASGDDDSKVH
LPTSNENRMD QIMVEFSHVR AICDSDQYYS MYIIVLDLLL WNEPLEKVRS EKLEKIMLAS
DFSDLRGAPQ LVSRLQQRIR QLEEIKNVFQ IQAKYLDVHG WQDRVALERD LTHCEDELFF
IMKAITTSQR KNEERATSQS SGVLRWALSA SEIVWHLMTS PKDPLVEFQL RNATYARTDN
IDGSNRNTIE IQRINGLNLL PSALYPQMIV PYVNEHRRPP QSEDDNMLRV DWFMLEAVAG
IPVLNHFEVT LFPLKVQLER ELGKKLFEYI FPGMGSNAFE NGAFSPFVIK HMRPLGEESG
SEDDESIAPV TPASSIASSS KDDSQASTLG PGSIELRLKP TLSLADHRPS GSPSKRIRGL
EMTPLHREPV RQLTPDEGPC SASRPSTSRI PKKASTDSLR PGSGQQSEIS LVSNQSVIGS
EGKPKKFGLQ RSSAKPNMAK GDKASDDLSQ MVSRASNFMT LAHVKINDVV LCLSYQGKGE
RNIEDVHDFV FRLPVLEYRN KTWSNLDLAL RLKKDVIKAL ISHTPAILGN KFSHHRPTKQ
QQRRLRELAS SSQVLSVTDI GQEIPTAPSS DGGGSVISHS SASERSESPP RRSFTSAASP
LGRSNSVSSS GAASSPNLPV ASDSRSAKSD HICSRDDGNH LFRDRVSRQV AGDQRSVNQR
NGNGHDNDVP DEG
//
