ID C1G0D1_PARBD Unreviewed; 659 AA.
AC C1G0D1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=HSF-type DNA-binding domain-containing protein {ECO:0000259|PROSITE:PS00434};
GN ORFNames=PADG_00321 {ECO:0000313|EMBL:EEH44032.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH44032.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH44032.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH44032.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|RuleBase:RU004020}.
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DR EMBL; KN275957; EEH44032.2; -; Genomic_DNA.
DR RefSeq; XP_010755781.1; XM_010757479.1.
DR AlphaFoldDB; C1G0D1; -.
DR STRING; 502780.C1G0D1; -.
DR GeneID; 22580178; -.
DR KEGG; pbn:PADG_00321; -.
DR VEuPathDB; FungiDB:PADG_00321; -.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_031225_0_0_1; -.
DR InParanoid; C1G0D1; -.
DR OMA; SALWEFK; -.
DR OrthoDB; 1117127at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF396; FLOCCULATION SUPPRESSION PROTEIN; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT DOMAIN 167..191
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS00434"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 71597 MW; A3FB62988E5813BC CRC64;
MNRIQEPPSR SPFSGPTDVS NKSRTIPVLS SSISPSDHPQ GDPMDLSPSS PATMAPPGNN
NGDSPETEHA GGASNNNTNS NTNSNTINHS TNGAAPASTM IGGDSGHALN QPIGAAAAAQ
QPKVVQTAFI HKLYSMLQDP GIQHLISWSS TNESFVMSPS QDFAKVLAQY FKHTNVSSFV
RQLNMYGFHK VSDVFHTGSP DSQMWEFKHG NGNFKKGDVA GLREIRRRAS RQTLIHRDSF
SGHKPNASQP GTPAEPTPDS SDSRVIDSRL LNTEHNIFEL YSRLSRVEEN YSMLASRCQA
LTESLVRCHQ WSNSMSHFVM SLVPDPENAI HRDAANMQRE VSRQLDAIRS LENPHESLLS
GRQPYFGSMT LHSGPPLSPR QMPQDDNRRS SMAQPPVPVH LSVSPRRYGS IGAANTSPDY
NRSHIPTHYS ATTATHQLHP LSAVSSAPGT NLGRRHTSAD IREHWASTTT NNTYPFGSIN
PNHPSSSSQW PPSPQRTGPP NNPVHNPMSM SMSMNMNMNP VPNAGDHQHV RDVLAKYEMG
GPRRQASSRH PTPPLPPIAI DPVAANTNTN NNNNNNTATT TPPHAPPHAS SSSSSTLNPE
SGWSIGGPKF PRPTDSSLPA TRRSSMASNV HSLLNPTATA ERPDEDDGAG EDRKRKRLQ
//
