ID C1GFX6_PARBD Unreviewed; 661 AA.
AC C1GFX6;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN ORFNames=PADG_06162 {ECO:0000313|EMBL:EEH50083.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH50083.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH50083.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH50083.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN275963; EEH50083.2; -; Genomic_DNA.
DR RefSeq; XP_010761374.1; XM_010763072.1.
DR AlphaFoldDB; C1GFX6; -.
DR STRING; 502780.C1GFX6; -.
DR GeneID; 22584955; -.
DR KEGG; pbn:PADG_06162; -.
DR VEuPathDB; FungiDB:PADG_06162; -.
DR eggNOG; KOG1842; Eukaryota.
DR HOGENOM; CLU_026440_1_0_1; -.
DR InParanoid; C1GFX6; -.
DR OMA; QASNFLH; -.
DR OrthoDB; 1441111at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd15761; FYVE1_Vac1p_like; 1.
DR CDD; cd15737; FYVE2_Vac1p_like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR021565; Rbsn_Rab-bd.
DR InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 2.
DR Pfam; PF11464; Rbsn; 1.
DR SMART; SM00064; FYVE; 2.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 1.
DR PROSITE; PS50178; ZF_FYVE; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 202..258
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 341..419
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74285 MW; 70BC5D91EECF3005 CRC64;
MPKRILGGGR VLGSGRSLTP TAPTPSPHRQ SRILSPTSSS VSLNSQGSTS QFSADTQDIV
SRISLGNGDS SSSRASMAAG SSRLACPICN EEMLTLLQLN RHLDDTHPNL EDDRQIEVKD
WFQIQVEKAK RFQPLAVLNQ KLKGLDVFES NNHTPLSVST PSRTPSGQIA SEPLKIVDPD
EVVTREHWQP RGLYDVCLEP LCQKRLSVTS GSVNCRKCGK LFCEEHTMYQ MKLSRSAQHE
PVRGYWCRVC ETCYKSREGY NDHNGQKRDH TSEFTKIRRQ KVDKAFLEVS RLEKRLTRLT
QLLSTLPPDQ IQPGANKLWS IAWQNDQRKK LEQSVVSWED DASVSRCPFC QQDFSSYTFR
RHHCRTCGRV VCGDPVTGCS LEIGLDIATN SQVSEKPTTA SETLSIDIRL CKECKSTIFD
RREVSQDLLK VPPDLRVYRN LAQFEKGIRL LLPRFQKLLS ALQDPENPPS PTQLTDAAKV
RRRLMDSFAQ YDIAARRIRD LPTSSPTQSK LQKAIYHQAT NFLHLHMLPL KSLPKVLKHA
TPHGTRFPIN DNTANGTKNA LATIKYGNHE NAGSATSLAS DNSSAISALE TEEKSLRERL
IVLEEQKFFV NEMVADANRR RKFDEASSLA QNAEDLNKEI DRVSGMIGQL DFEGLYVNKL
G
//
