ID C1GHE6_PARBD Unreviewed; 843 AA.
AC C1GHE6;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Anaphase-promoting complex subunit 4 {ECO:0000256|ARBA:ARBA00016067};
GN ORFNames=PADG_06682 {ECO:0000313|EMBL:EEH50603.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH50603.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH50603.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH50603.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN275965; EEH50603.2; -; Genomic_DNA.
DR RefSeq; XP_010762053.1; XM_010763751.1.
DR AlphaFoldDB; C1GHE6; -.
DR STRING; 502780.C1GHE6; -.
DR GeneID; 22585352; -.
DR KEGG; pbn:PADG_06682; -.
DR VEuPathDB; FungiDB:PADG_06682; -.
DR eggNOG; KOG4640; Eukaryota.
DR HOGENOM; CLU_011501_0_0_1; -.
DR InParanoid; C1GHE6; -.
DR OMA; FEPMKEF; -.
DR OrthoDB; 2722114at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024789; APC4.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR024790; APC4_long_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13260; ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4; 1.
DR PANTHER; PTHR13260:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 4; 1.
DR Pfam; PF12896; ANAPC4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 26..143
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 296..495
FT /note="Anaphase-promoting complex subunit 4 long"
FT /evidence="ECO:0000259|Pfam:PF12896"
FT REGION 805..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..830
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 93464 MW; 3C8EFA28F8E85D13 CRC64;
MNPQHLPKLA TLAEKTLASK CKPGSMSYCP TMDLIALASA DERVDVFRLN GQRVFGGVYG
GGGRGGSGRE VRGLKWKGNG HLLAVVCSDN IIRILSAYSG KIVHQLPCGP LLASHSTASV
PPSSLSPAAD AVTCVSCLGW GMNFTDDRSA LKNLQDAERR ITVQDLLTTH SQLSKIAQLK
ADLPRELAML DMERSLPKLS TLPSTGNDDD VFGTRASIDS IFHATNKVTG DSVDVLLAGF
DDGTIHLRIF DCFDIGLFPV GGSLGDSTAN RILLHSSHPI SSTHSLLFST ESNLLLVNLD
LRFITRCGRY LSLLASKVTQ LQNLLRYIKQ VQAQIHLEWK NAQDLPGRYI RNVTEDLQDK
CSCDFVTAAY HLLVTGDCFP PLKEFLVEIL GERGHKRWEK AVTSGYEALR RLTHESLLPA
LERCGVLLSR LLGLSKFHKL SPILGLETTD LEKCQETIDC LNLLSHKLLI HSSRELLEFA
AFSKWLRHEV DLQAADPLSS TYEELTESSD SLDHAQTLSY IQGAMTRSAL QDFIQPAPAQ
SQPDRWETVG RDSSFYETYK KLLRQQDQKK WTDRIDIPLL GDLTSRLGLQ CEKVFKQIAE
TQRRGILHRS PLSLDPDCSA DVIDMAMNFS PFENSTYASV YIASKSKSSS WILYLYRVLL
NTVNGVSSTK AAFLAVLNLQ NGNIKQIKFV EDGTMMLLLS DGNTHLVSFP YLPNPDGLFH
PNYIRLSDSP EASATSSTLP SGIAEDDITH LYLADPQQHA DFVKHTFTGQ GNMEPVEFQV
NGRKGRRVVC VLYADRLRYS VFDMDSSEDG QVDEENSEED PEDVNWGDTG DGDGDWDNMK
VEK
//
