ID C1GHH4_PARBD Unreviewed; 547 AA.
AC C1GHH4;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=GAT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PADG_06710 {ECO:0000313|EMBL:EEH50631.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH50631.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH50631.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH50631.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBUNIT: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
CC {ECO:0000256|ARBA:ARBA00011446}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KN275965; EEH50631.2; -; Genomic_DNA.
DR RefSeq; XP_010762064.1; XM_010763762.1.
DR AlphaFoldDB; C1GHH4; -.
DR STRING; 502780.C1GHH4; -.
DR GeneID; 22585376; -.
DR KEGG; pbn:PADG_06710; -.
DR VEuPathDB; FungiDB:PADG_06710; -.
DR eggNOG; ENOG502S1ZS; Eukaryota.
DR HOGENOM; CLU_031989_0_1_1; -.
DR InParanoid; C1GHH4; -.
DR OMA; MMTLIET; -.
DR OrthoDB; 2148459at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd21383; GAT_GGA_Tom1-like; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR045007; LSB5.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47789; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR PANTHER; PTHR47789:SF1; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR Pfam; PF03127; GAT; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 43..168
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 203..292
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 294..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 60172 MW; 69D6CF9AE50C5CA0 CRC64;
MRTILTGLRR LSHHPAQSVF RSSSHPESPE AIILTEVNAF CESGGPNNTG DEFLHLPAIV
EAAESSPNAA KEAANLIRHV LSNPSSKKGY RQYNAVMLIR ILVDNPGETF SRNFDAKFVS
IIRDLLRDGR DMSVQQVLRE TLEYLAVQKS NDPHLAPLVQ MWKKEKEKFE RTTGVSAGPW
VQPQIAGQHD NFVTHPHRNG VLPTPDELSA RISEANTSAS LLLQLVQSTP STEFYKNDLL
REFSQRCQAA ARSIQEYINA SNPAPDEDTM LTLIETNDKL AVALSKYQRA ALVARKHTSR
MQPNPNDPNA TLQQPEQPET QQPHPQPLPP PDQVRNTDAQ TAKRSGPLFS MSLRNLSKYL
PDKHPQTDHQ SQYQQPHHPS QTPQTPPSNL SRIATTKTTP PSAVSPVNTT PPQPPFSSTA
PTSKGYRPSP PPNTTPSNPT YQYNSSDFQV ENPFADTHSS SHFDNNSDNG SHHGTRTWDT
SRTRNLGADT QPITSSTYYP NTGDGLPDSN MAAARGPDSV PGTLTGAEAR TLSATERFYG
ALAGRKG
//
