ID   C1GIW8_PARBD            Unreviewed;      1067 AA.
AC   C1GIW8;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=CNH domain-containing protein {ECO:0000259|PROSITE:PS50219};
GN   ORFNames=PADG_07204 {ECO:0000313|EMBL:EEH42384.2};
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH42384.2, ECO:0000313|Proteomes:UP000001628};
RN   [1] {ECO:0000313|EMBL:EEH42384.2, ECO:0000313|Proteomes:UP000001628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18 {ECO:0000313|EMBL:EEH42384.2,
RC   ECO:0000313|Proteomes:UP000001628};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
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DR   EMBL; KN275966; EEH42384.2; -; Genomic_DNA.
DR   RefSeq; XP_010762459.1; XM_010764157.1.
DR   AlphaFoldDB; C1GIW8; -.
DR   STRING; 502780.C1GIW8; -.
DR   GeneID; 22585745; -.
DR   KEGG; pbn:PADG_07204; -.
DR   VEuPathDB; FungiDB:PADG_07204; -.
DR   eggNOG; KOG2063; Eukaryota.
DR   HOGENOM; CLU_004190_1_1_1; -.
DR   InParanoid; C1GIW8; -.
DR   OMA; LFRLPNF; -.
DR   OrthoDB; 38195at2759; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR   InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR   InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF10366; Vps39_1; 1.
DR   Pfam; PF10367; Vps39_2; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50236; CHCR; 1.
DR   PROSITE; PS50219; CNH; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT   DOMAIN          18..359
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          51..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1067 AA;  118052 MW;  13BD562DF3496DC8 CRC64;
     MLSAFTASPL VKLKQRDKSR IESFLAYGDR LLVGLNTGTL RIYRINESEN AQNENEGANT
     NGEGGLGTSG RSYSGKRDRA TSESVDVSKV KPTDLLREQE KFSRHKIEQL AIIKEAGILI
     SLSNGCVSIH DLQTYELQQQ LTRTKGATAF AVASNIIKDP STGVPSIVSR LAVAVKRKLM
     LWMWLDMELE DDTTEITLAS GIKTLTWANG TKLVAGLSSS YVMVDVESLK VTDILGPGSI
     GGPGGQETGR LGVGVASMSY IGMGGAAPKP LATRLSDGEI LLAKDVNTHF IDTDGNSLGR
     RQIPWTTAPE AVGYSYPYLL ALQEPSKGTL EVRNPETLSL LQSISLPSAS MLHIPQPTIS
     LAHAGKGFLV GSERIIWRMG ALDYDSQIDS LIEQGCLDEA ISLISMLEDA LLRDKQGRLR
     QAKLQKAEAL FDEKKYRDSL DLFTEACAPP ELVIRKYPRL IAGSLSKLDE DKSDGEETDA
     EEQTPQNTNG TTINGVEAAA ENSPKIKTPA GYAPSVRSIL KGKSDDASET GSIRGKTVGV
     KFADKPLQGR DLKSAARALQ GFLADIRRRL QRFLNPDGTI TTLAMELNNE TDDFARSVRN
     VLGLSPYDNP DEIAVKLRET ATLVDTTLFR AHMFATPSLA GSLFRIANFC DPDVVMEKLE
     ETGRYNDLID FLFGKKLHRA ALERLRKFGQ AEKDEKFAAA PQLCGPERTV AYLQNLPPEM
     IDLILEFAEW PMQVQPQLGM EIFLADTENA ESLQRDKVLE FLRGIDSNLA IQYLEHIIGE
     LNEMSPDMHQ WLLSLYLERL KQWKGGDISV QQEFESEDEW RKGMEKFQDM LKSSEQYSPA
     RMLDRLPRND PDFFEARAII FSKMGQHRQA LEIYVFKLED PEKAEEYCNH IHRSEETRST
     KTDTAQRVAP TDLEGGQLSI YHTLLSLYLS PPHNYKPQYG PAVEILAKHG SRLPASSTLD
     LIPEKLPVHE LEFYFRGRMR AANSIANEGR IVAALRKVQN AHVQADLHLG QETLAGDNKG
     RNRFVTISEE RVCGVCHKRL GGSVISVFPN NTVVHLGCAG KWSTAGG
//