ID C1GL12_PARBD Unreviewed; 1593 AA.
AC C1GL12;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Glycogen debranching enzyme {ECO:0000313|EMBL:EEH43199.2};
GN ORFNames=PADG_08019 {ECO:0000313|EMBL:EEH43199.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH43199.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH43199.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH43199.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN275969; EEH43199.2; -; Genomic_DNA.
DR RefSeq; XP_010763279.1; XM_010764977.1.
DR STRING; 502780.C1GL12; -.
DR GeneID; 22586395; -.
DR KEGG; pbn:PADG_08019; -.
DR VEuPathDB; FungiDB:PADG_08019; -.
DR eggNOG; KOG3625; Eukaryota.
DR HOGENOM; CLU_001517_2_0_1; -.
DR InParanoid; C1GL12; -.
DR OMA; YEEGHVH; -.
DR OrthoDB; 1427975at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004134; F:4-alpha-glucanotransferase activity; IEA:InterPro.
DR GO; GO:0004135; F:amylo-alpha-1,6-glucosidase activity; IEA:InterPro.
DR GO; GO:0005980; P:glycogen catabolic process; IEA:InterPro.
DR CDD; cd11327; AmyAc_Glg_debranch_2; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR010401; AGL/Gdb1.
DR InterPro; IPR032788; AGL_central.
DR InterPro; IPR029436; AGL_euk_N.
DR InterPro; IPR032792; AGL_glucanoTrfase.
DR InterPro; IPR032790; GDE_C.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10569; GLYCOGEN DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR10569:SF2; GLYCOGEN DEBRANCHING ENZYME; 1.
DR Pfam; PF06202; GDE_C; 1.
DR Pfam; PF14701; hDGE_amylase; 1.
DR Pfam; PF14702; hGDE_central; 1.
DR Pfam; PF14699; hGDE_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT DOMAIN 46..152
FT /note="Eukaryotic glycogen debranching enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14699"
FT DOMAIN 155..596
FT /note="Glycogen debranching enzyme glucanotransferase"
FT /evidence="ECO:0000259|Pfam:PF14701"
FT DOMAIN 776..1018
FT /note="Glycogen debranching enzyme central"
FT /evidence="ECO:0000259|Pfam:PF14702"
FT DOMAIN 1092..1575
FT /note="Glycogen debranching enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06202"
FT REGION 749..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 179014 MW; F736F7209FEFE4EB CRC64;
MSPPCASAPK RSQHGVYLLP LTDDGAPDVA HGYVSLPHPT DPPYILRFVI EGSSAVCRRG
RLWVNIPHPG AQFERGFFRE YLLTPSFTHA IEIDIPITTP GAFAFYITYS PPPELPVATF
PSPRQIQAQD PAQVQLRSPT HYINVAPTIS LNNQTLPLAS VSVISLLSKF VGSNPSDWNK
HLLSIARRGY NMVHFTPIMA RGESNSPYSI ADHLTFDRCC FPNGESDVAN MVSRMESQYG
LLPLTDVVWN HTANNTEWLQ EHPEAGYNVE TAPWLEAAVE LDDTLLRYSE QLGQLGLPTQ
FDNVNDLLSV MNQMRANVID KIRLWEFYAV DVQRDVEATI RAYQSGDVRI PEGGFGDHTI
GGLGEIKGWS LKEKAGFLRD RGLLNKDRLL GRYGRVVEPA VAAALLTALY GRYDAETSDI
PRIRSDLSKI FDEVNLPLFL EFDKDVLEIF DQLFNRIKYL RLDENGPKLG PVTKENPLIE
TYFTRLPLNE KTAKHNRNTL ALVNNGWVWN ADAMRDNAGP HSRAYLLRQV IIWGDCVKLR
YGSCRDDNPY LWDYMASYTK LMAKYFAAFR IDNCHSTPLA VAAYLLDEAR RVRPNLAVFA
ELFTGSEEMD YLFTKRLGLN ALIREAMQSW STAELSRLVH RHGGRPIGSF DIDLPTDDFP
RENGINGGSK GNGKNCGARC ETIKHVREMP VQALFMDCTH DNEMPAQKRE ARDTLPNASL
VAMCASASGS VMGYDEIYPA HLDLVQETRR YSSSVEPSEG GSADPSDKPS IIGKEGIGGA
KRLLNDLHTK MAVEGYDETH IHHDGEYITV HRVQPDTRRG VFLIAHTAFP GANGGALDPV
CLTGTKAKLI GAWRLEVDDS DKAKEAVLGD KEYLRGLPSQ VISLDGVLIS EKEDSTVISM
PQSFPPGSIV LLETWIPCAG LSQELSTFIT SGAVEAFHKL DLIDLNFVLY RCNAEERDSS
DGKDGVYNVP NFGPLAYAGL QGWWSVLETI VKHDDLGHPL CDHLRTGQWA LDFIVGRMER
AIELHGYERL QLPTAWLRER FDVIRKVPNF LLPRYFSMIV QTAYYAAWRR GIQLFNGIRH
GTHFVHALAT VSIQMVGYVK SGSLYPNKLV PSLAAGLPHF STDWARCWGR DVFISLRGLL
LCTGRFDAAK DHIISFASVI KHGMIPNLLG SGKLPRYNSR DSVWFFLQAI QNYVTMVPDG
IQLLEEKVPR RFLPYDDTWF SFDDERAYSR SSTIEEIIQE VLQRHASGLS FREYNAGPQL
DMQMKPEGFQ VDIHVDWETG FIFGGNMWNC GTWMDKMGES EKAANRGHPG TPRDGAAIEI
TGLLYSALRW VSKLHEEGRY KYAGVTTNSN ETIKFSEWAQ RIQSNFDRAY YIPVLSSHDA
QHDIDPTIVH RRGIYKDLYK SSSPYKDYQL RPNFAIAMTV APDLFKLENA IHALVVADKV
LRGPVGMATL DPDDLNYRPY YNNAEDSEDF ATSKGRNYHQ GPEWVWPLGF FLRALLRFEI
IRRKSLGKES KHEGGERDMS GREEAFQLVA SRLEGCKKMI AESPWKGLAE LTNKSGEFCA
DSAPTQAWSA ACLLEVYYDA AQHQQEDRPG DEG
//
