ID C1GZG5_PARBA Unreviewed; 856 AA.
AC C1GZG5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=DUF323 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PAAG_03909 {ECO:0000313|EMBL:EEH41988.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH41988.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH41988.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037882}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN294000; EEH41988.1; -; Genomic_DNA.
DR RefSeq; XP_002794316.1; XM_002794270.2.
DR AlphaFoldDB; C1GZG5; -.
DR STRING; 502779.C1GZG5; -.
DR GeneID; 9097367; -.
DR KEGG; pbl:PAAG_03909; -.
DR VEuPathDB; FungiDB:PAAG_03909; -.
DR eggNOG; ENOG502QS9T; Eukaryota.
DR HOGENOM; CLU_006921_0_1_1; -.
DR OMA; FKHWHPT; -.
DR OrthoDB; 1416at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024775; DinB-like.
DR InterPro; IPR019257; MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR NCBIfam; TIGR03439; methyl_EasF; 1.
DR PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR Pfam; PF12867; DinB_2; 1.
DR Pfam; PF03781; FGE-sulfatase; 2.
DR Pfam; PF10017; Methyltransf_33; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 21..326
FT /note="Histidine-specific methyltransferase SAM-dependent"
FT /evidence="ECO:0000259|Pfam:PF10017"
FT DOMAIN 365..485
FT /note="DinB-like"
FT /evidence="ECO:0000259|Pfam:PF12867"
FT DOMAIN 545..679
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT DOMAIN 755..854
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT REGION 604..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 96443 MW; C33C1FBA6321E855 CRC64;
MALGSVAITD IHVNDFQGSL ANDIYNGLNP PDREPKSMPT LLLYSTEGLR RFEDITYVDE
YYLTNAEIEA LTMHAAKIVN QIPENAQLVE LGSGNLRKIE ILLNEFERKN KPVNYFALDL
SLEELQRTFA AIPSKGYKYV KCRGLHGTYD DALIWLTKPE NRQTPTCILF MGSSIGNFTR
PEAAQFLKRF SELLGPSDSM LIGIDSCKDP EKVFKAYNDS QGVTKDFYKI GLSYANSVLG
FKAFKKEDWE VTGLYDKSDG CHRAYYVPKK DITFKGVVLK KGEKILFERA FKYGPEDCEE
LFKQALLTPV ARFGNSAGEY YLHLLSSCCL EMPTRAAHYA ADATPKVSDF ESLWKAWDMV
TISMIPKHEL LSKPIRLRNA LIFYLGHTPT FLDIHLTRAT NGIPTEPAKY HSIFERGIDP
DVDNPEICHA HSEIPDEWPA IGEILAYRDA VRNRTRPLLR DGKMGRRLAE ALWLSFEHEA
MHLETFLYML LQSDKTLPPP GIPRPDFEAL AKQSTSNSTL NAWFTIPEQK ISIGLEDPGS
DVIPKQSFGW DNEKPKRTAV VPAFKAKARP ITNGEYAKYL EQNHITAIPA SWIDLAPRTK
GNKQNGYVNG ASSLRNGDSQ TNRTNASASK DFLEKFAIRT VFGPVPLKWV LDWPVMASYN
ELQGYAKFVN CRIPSFEEVR SIYKYSALFK SKETNGVPSL TNGNGDEVNG IDKGFTKLVD
PAKDMHGNPR TPDHQPVQSH SANLMPVYID LDDDCNVGFK HWHPTPVTQN GNKLSGHGEL
GGVWEWTATP FHAHEGFKAM DLYPGYSADF FDGKHNIVLG GSWATHPRIA GRTTFVNWYQ
RNYAYAWAGA RLVRDI
//
