ID C1H1W1_PARBA Unreviewed; 550 AA.
AC C1H1W1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=4-coumarate-CoA ligase {ECO:0000313|EMBL:EEH33848.1};
GN ORFNames=PAAG_04897 {ECO:0000313|EMBL:EEH33848.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH33848.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH33848.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
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DR EMBL; KN294003; EEH33848.1; -; Genomic_DNA.
DR RefSeq; XP_002793368.1; XM_002793322.1.
DR AlphaFoldDB; C1H1W1; -.
DR STRING; 502779.C1H1W1; -.
DR GeneID; 9096413; -.
DR KEGG; pbl:PAAG_04897; -.
DR VEuPathDB; FungiDB:PAAG_04897; -.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_2_1; -.
DR OMA; SISCNQA; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF265; ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EEH33848.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT DOMAIN 29..394
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 445..528
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 550 AA; 60842 MW; E9AA02A948822E9F CRC64;
MEYFKPEQYI ELPTKDLLSW IFDSPPYDQD RPIYIDAKDP SKSISCNQAR KIIRQLIAGL
RAAGFKKGDC LSIHSFNDIH YSMIFLAVIG AGGVFAGTNP GYTQFELSHT IKTAKVTFLI
SEPEILDNLV AAAESNNIPT SNIWIFNTQG QPVPAGHKSW TELFKHGEED WIRFDDPEIC
KTTTAARLFS SGTTGLPKAA VISHLNLIGQ HIFVHDTKPP PHQISRVVAI PCFHAAAVPA
THVSALKAGI TLYIIRRFEL LPFLEVIDKY SITDVSTVPP MAVGIVKSPF AKKDYLKKAK
SGACGAAPLD KDVQSAFRSM LSPGAPYTQV WGMTETTCIA TMFYYPEHDD TGSVGRQIPS
LEIKLIDNGG KNISAYGVRG EICVRGPTVI TGYFENPAAN AESFDGDWFK TGDIGYCEEK
TKKWYIVDRK KELIKVRGFQ VAPPEIEAVL LSHPLIMDAA VIGVTFKEPG EEKIEHPRAY
VVRQPVPASQ NLTERELQEF AGAKLAKYKY LSGGVKFVES IPKNPSGKIL KRQLRENAKK
EIELGLLAKL
//
